Cited 2 times in
Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer
DC Field | Value | Language |
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dc.contributor.author | 강정현 | - |
dc.contributor.author | 박준성 | - |
dc.contributor.author | 백승혁 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 윤동섭 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 임진홍 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2018-10-11T08:54:44Z | - |
dc.date.available | 2018-10-11T08:54:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163458 | - |
dc.description.abstract | Purpose: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. Methods: This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume). Results: All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0-2.8] in KRG group vs. median, 1.89 [range, 1.1-3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% vs. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis. Conclusion: Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Surgical Society | - |
dc.relation.isPartOf | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Jeonghyun Kang | - |
dc.contributor.googleauthor | Joon Seong Park | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Jin Hong Lim | - |
dc.contributor.googleauthor | Seung Hyuk Baik | - |
dc.contributor.googleauthor | Dong Sup Yoon | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.4174/astr.2018.95.3.161 | - |
dc.contributor.localId | A00080 | - |
dc.contributor.localId | A01672 | - |
dc.contributor.localId | A01827 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A02548 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03411 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J00180 | - |
dc.identifier.eissn | 2288-6796 | - |
dc.identifier.pmid | 30182023 | - |
dc.subject.keyword | Colonic neoplasms | - |
dc.subject.keyword | Folfox protocol | - |
dc.subject.keyword | Oxaliplatin | - |
dc.subject.keyword | Splenomegaly | - |
dc.contributor.alternativeName | Kang, Jeong Hyun | - |
dc.contributor.alternativeName | Park, Joon Seong | - |
dc.contributor.alternativeName | Baik, Seung Hyuk | - |
dc.contributor.alternativeName | Ahn, Sung Gwe | - |
dc.contributor.alternativeName | Yoon, Dong Sup | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Lim, Jin Hong | - |
dc.contributor.alternativeName | Jeong, Joon | - |
dc.contributor.affiliatedAuthor | Kang, Jeong Hyun | - |
dc.contributor.affiliatedAuthor | Park, Joon Seong | - |
dc.contributor.affiliatedAuthor | Baik, Seung Hyuk | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Gwe | - |
dc.contributor.affiliatedAuthor | Yoon, Dong Sup | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Lim, Jin Hong | - |
dc.contributor.affiliatedAuthor | Jeong, Joon | - |
dc.citation.volume | 95 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 167 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL TREATMENT AND RESEARCH, Vol.95(3) : 161-167, 2018 | - |
dc.identifier.rimsid | 60407 | - |
dc.type.rims | ART | - |
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