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Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer

DC FieldValueLanguage
dc.contributor.author강정현-
dc.contributor.author박준성-
dc.contributor.author백승혁-
dc.contributor.author안성귀-
dc.contributor.author윤동섭-
dc.contributor.author이강영-
dc.contributor.author임진홍-
dc.contributor.author정준-
dc.date.accessioned2018-10-11T08:54:44Z-
dc.date.available2018-10-11T08:54:44Z-
dc.date.issued2018-
dc.identifier.issn2288-6575-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163458-
dc.description.abstractPurpose: This study investigated how adding Korean red ginseng extract (KRG) to folinic acid, fluorouracil and oxaliplatin (FOLFOX) chemotherapy affected the rate of splenomegaly in colon cancer. Methods: This retrospective study analyzed 42 patients who were randomly assigned to receive a FOLFOX regimen with or without KRG. Spleen volume change was assessed by computed tomography scans measured before surgery (presurgery volume) and 3 weeks after cessation of the 12th cycle of FOLFOX (postchemotherapy volume). Results: All patients showed increased spleen volume. No difference was observed in median presurgery and postchemotherapy volume between the KRG and control groups. However, a ratio defined as postchemotherapy volume divided by presurgery volume was significantly lower in the KRG group than the control group (median, 1.38 [range, 1.0-2.8] in KRG group vs. median, 1.89 [range, 1.1-3.0] in control group, P = 0.028). When splenomegaly was defined as a >61% increase in spleen volume, the rate of splenomegaly was significantly lower in the KRG group than the control group (28.6% vs. 61.9%, P = 0.03). KRG consumption was inversely associated with developing splenomegaly in multivariate analysis. Conclusion: Adding KRG during FOLFOX chemotherapy for colon cancer might protect against oxaliplatin-induced splenomegaly. The protective effect of Korean red ginseng should be investigated with further research.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Surgical Society-
dc.relation.isPartOfAnnals of Surgical Treatment and Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProtective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJeonghyun Kang-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorJin Hong Lim-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorDong Sup Yoon-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.4174/astr.2018.95.3.161-
dc.contributor.localIdA00080-
dc.contributor.localIdA01672-
dc.contributor.localIdA01827-
dc.contributor.localIdA02231-
dc.contributor.localIdA02548-
dc.contributor.localIdA02640-
dc.contributor.localIdA03411-
dc.contributor.localIdA03727-
dc.relation.journalcodeJ00180-
dc.identifier.eissn2288-6796-
dc.identifier.pmid30182023-
dc.subject.keywordColonic neoplasms-
dc.subject.keywordFolfox protocol-
dc.subject.keywordOxaliplatin-
dc.subject.keywordSplenomegaly-
dc.contributor.alternativeNameKang, Jeong Hyun-
dc.contributor.alternativeNamePark, Joon Seong-
dc.contributor.alternativeNameBaik, Seung Hyuk-
dc.contributor.alternativeNameAhn, Sung Gwe-
dc.contributor.alternativeNameYoon, Dong Sup-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameLim, Jin Hong-
dc.contributor.alternativeNameJeong, Joon-
dc.contributor.affiliatedAuthorKang, Jeong Hyun-
dc.contributor.affiliatedAuthorPark, Joon Seong-
dc.contributor.affiliatedAuthorBaik, Seung Hyuk-
dc.contributor.affiliatedAuthorAhn, Sung Gwe-
dc.contributor.affiliatedAuthorYoon, Dong Sup-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorLim, Jin Hong-
dc.contributor.affiliatedAuthorJeong, Joon-
dc.citation.volume95-
dc.citation.number3-
dc.citation.startPage161-
dc.citation.endPage167-
dc.identifier.bibliographicCitationAnnals of Surgical Treatment and Research, Vol.95(3) : 161-167, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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