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The Role of Saikosaponins in Therapeutic Strategies for Age-related Diseases

 Byeong Mo Kim 
 Oxidative Medicine and Cellular Longevity, Vol.2018 : 8275256, 2018 
Journal Title
 Oxidative Medicine and Cellular Longevity 
Issue Date
Apoptosis/drug effects ; Cardiovascular Diseases/drug therapy* ; Cardiovascular Diseases/pathology ; Cell Cycle Checkpoints/drug effects ; Humans ; Liver Diseases/drug therapy ; Liver Diseases/pathology ; Neoplasms/drug therapy* ; Neoplasms/pathology ; Neurodegenerative Diseases/drug therapy* ; Neurodegenerative Diseases/pathology ; Obesity/pathology ; Obesity/prevention & control ; Oleanolic Acid/analogs & derivatives* ; Oleanolic Acid/chemistry ; Oleanolic Acid/pharmacology ; Oleanolic Acid/therapeutic use ; Oxidative Stress/drug effects ; Saponins/chemistry ; Saponins/pharmacology ; Saponins/therapeutic use*
As life expectancy increases, elderly populations tend to spend an increasing number of years in poor health, with chronic age-related diseases and disability. Therefore, the development of therapeutic strategies to treat or prevent multiple pathophysiological conditions in the elderly may improve health-adjusted life expectancy and alleviate the potential economic and social burdens arising from age-related diseases. Bioactive natural products might represent promising new drug candidates for the treatment of many chronic age-related diseases, including cancer, Alzheimer's disease, cardiovascular disease, obesity, and liver disease. Here, we discuss a therapeutic option using saikosaponins, which are triterpene saponins isolated from Bupleurum, against a variety of age-related diseases. Understanding the underlying mechanisms of natural products like saikosaponins in the treatment of age-related diseases may help in the development of diverse natural product-derived compounds that may be effective against a number of chronic health problems.
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5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
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