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Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey

Authors
 Jae Won Hong  ;  Cheol Ryong Ku  ;  Jung Hyun Noh  ;  Kyung Soo Ko  ;  Byoung Doo Rhee  ;  Dong-Jun Kim 
Citation
 PLoS One, Vol.10(3) : e0118866, 2015 
Journal Title
 PLoS One 
Issue Date
2015
MeSH
Adult ; Albuminuria/epidemiology* ; Cardiovascular Diseases/epidemiology* ; Cross-Sectional Studies ; Female ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Nutrition Surveys ; Prevalence ; Republic of Korea ; Risk Factors
Abstract
BACKGROUND: Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range ('low-grade albuminuria') are associated with cardiovascular morbidity and mortality in the general population. METHODS: We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES). RESULTS: The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively. CONCLUSION: Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163345
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DOI
10.1371/journal.pone.0118866
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
구철룡(Ku, Cheol Ryong) ORCID logo https://orcid.org/0000-0001-8693-9630
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