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The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis

Authors
 Keum Hwa Lee  ;  Jae Won Yang  ;  Jin Young Cho  ;  Joo Yup Lee  ;  Eun Kyung Lim  ;  Michael Eisenhut  ;  Dong Yeon Jeong  ;  Johanna Steingroever  ;  Jae Il Shin 
Citation
 Childhood Kidney Diseases, Vol.22 : 17-21, 2018 
Journal Title
 Childhood Kidney Diseases 
ISSN
 2384-0250 
Issue Date
2018
Keywords
Thymic stromal lymphopoietin (TSLP) ; glomerulonephritis ; T-helper type 2 (Th2)-dominant immune response ; TSLP transgenic mice
Abstract
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.
Files in This Item:
T201802647.pdf Download
DOI
10.3339/jkspn.2018.22.1.17
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163267
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