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The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis

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dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2018-09-28T08:57:19Z-
dc.date.available2018-09-28T08:57:19Z-
dc.date.issued2018-
dc.identifier.issn2384-0250-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163267-
dc.description.abstractThymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at the induction phase of the Th2 response through polarization of dendritic cells to drive Th2 cell differentiation and at the effector phase of the response, by promoting the expansion of activated T cells and their secretion of Th2 cytokines and TSLP. In transgenic mice with TSLP overexpression, it has been reported that TSLP leads to the development of mixed cryoglobulinemic membranoproliferative glomerulonephritis. In addition, TSLP can play an important role in the pathogenesis of IgA nephropathy and systemic lupus erythematosus-related nephritis. From our knowledge of the role of TSLP in the kidney, further studies including the discovery of new therapies need to be considered based on the relationship between TSLP and glomerulonephritis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Pediatric Nephrology-
dc.relation.isPartOfChildhood Kidney Diseases-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorJae Won Yang-
dc.contributor.googleauthorJin Young Cho-
dc.contributor.googleauthorJoo Yup Lee-
dc.contributor.googleauthorEun Kyung Lim-
dc.contributor.googleauthorMichael Eisenhut-
dc.contributor.googleauthorDong Yeon Jeong-
dc.contributor.googleauthorJohanna Steingroever-
dc.contributor.googleauthorJae Il Shin-
dc.identifier.doi10.3339/jkspn.2018.22.1.17-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ00524-
dc.identifier.eissn2384-0242-
dc.subject.keywordThymic stromal lymphopoietin (TSLP)-
dc.subject.keywordglomerulonephritis-
dc.subject.keywordT-helper type 2 (Th2)-dominant immune response-
dc.subject.keywordTSLP transgenic mice-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.alternativeNameLee, Geum Hwa-
dc.contributor.affiliatedAuthorShin, Jae Il-
dc.contributor.affiliatedAuthorLee, Geum Hwa-
dc.citation.volume22-
dc.citation.startPage17-
dc.citation.endPage21-
dc.identifier.bibliographicCitationChildhood Kidney Diseases, Vol.22 : 17-21, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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