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Recent advances of animal model of focal segmental glomerulosclerosis

Authors
 Jae Won Yang  ;  Anne Katrin Dettmar  ;  Andreas Kronbichler  ;  Heon Yung Gee  ;  Moin Saleem  ;  Seong Heon Kim  ;  Jae Il Shin 
Citation
 CLINICAL AND EXPERIMENTAL NEPHROLOGY, Vol.22(4) : 752-763, 2018 
Journal Title
 CLINICAL AND EXPERIMENTAL NEPHROLOGY 
ISSN
 1342-1751 
Issue Date
2018
Keywords
Animal model ; Focal segmental glomerulosclerosis ; Podocyte
Abstract
In the last decade, great advances have been made in understanding the genetic basis for focal segmental glomerulosclerosis (FSGS). Animal models using specific gene disruption of the slit diaphragm and cytoskeleton of the foot process mirror the etiology of the human disease. Many animal models have been developed to understand the complex pathophysiology of FSGS. Therefore, we need to know the usefulness and exact methodology of creating animal models. Here, we review classic animal models and newly developed genetic animal models. Classic animal models of FSGS involve direct podocyte injury and indirect podocyte injury due to adaptive responses. However, the phenotype depends on the animal background. Renal ablation and direct podocyte toxin (PAN, adriamycin) models are leading animal models for FSGS, which have some limitations depending on mice background. A second group of animal models were developed using combinations of genetic mutation and toxin, such as NEP25, diphtheria toxin, and Thy1.1 models, which specifically injure podocytes. A third group of animal models involves genetic engineering techniques targeting podocyte expression molecules, such as podocin, CD2-associated protein, and TRPC6 channels. More detailed information about podocytopathy and FSGS can be expected in the coming decade. Different animal models should be used to study FSGS depending on the specific aim and sometimes should be used in combination.
Full Text
https://link.springer.com/article/10.1007%2Fs10157-018-1552-8
DOI
10.1007/s10157-018-1552-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Gee, Heon Yung(지헌영) ORCID logo https://orcid.org/0000-0002-8741-6177
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163218
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