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Sensitization to Various Minor House Dust Mite Allergens is greater in patients with Atopic Dermatitis Than in Those with Respiratory Allergic Disease

Authors
 K. H. Park  ;  J. Lee  ;  J.‐Y. Lee  ;  S. C. Lee  ;  D. W. Sim  ;  J. U. Shin  ;  C. O. Park  ;  J.‐H. Lee  ;  K. H. Lee  ;  K. Y. Jeong  ;  J.‐W. Park 
Citation
 Clinical and Experimental Allergy, Vol.48(8) : 1050-1058, 2018 
Journal Title
 Clinical and Experimental Allergy 
ISSN
 0954-7894 
Issue Date
2018
Keywords
allergic rhinitis ; asthma ; atopic dermatitis ; house dust mite ; recombinant allergen
Abstract
BACKGROUND: Various allergenic proteins are produced by house dust mites (HDM). However, the allergenicity and clinical implications of these allergens are unknown. OBJECTIVE: The purpose of this study was to identify allergens in Dermatophagoides farinae and elucidate the sensitization profiles to these in Korean patients suffering from respiratory (allergic rhinitis and/or asthma) and atopic dermatitis symptoms. METHODS: IgE reactivities in sera from 160 HDM allergy patients were analysed by one- and two-dimensional gel electrophoresis and immunoblotting. IgE-reactive components were identified by liquid chromatography-coupled electrospray ionization-tandem mass spectrometry. Nine recombinant mite allergens (Der f 1, Der f 2, Der f 10, Der f 11, Der f 13, Der f 14, Der f 30, Der f 32 and Der f Alt a 10) were produced, and the IgE reactivity in sera to each was determined by ELISAs. RESULTS: Der f 1 and Der f 2 were recognized by IgE in serum samples from 88.1% and 78.1% of all patients, respectively. Patients with respiratory allergies were mainly sensitized to these major allergens, whereas patients with atopic dermatitis symptoms showed polysensitization to major and minor allergen components (including Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10). CONCLUSIONS: Patients with respiratory allergic disease sensitize to major allergen components of HDM. Those with atopic dermatitis were sensitized to a broader range of minor allergen components of HDM (Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10).
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13164
DOI
10.1111/cea.13164
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers
Yonsei Authors
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
박창욱(Park, Chang Ook) ORCID logo https://orcid.org/0000-0003-3856-1201
신정우(Shin, Jung U) ORCID logo https://orcid.org/0000-0001-5259-6879
이광훈(Lee, Kwang Hoon)
이상철(Lee, Sang Chul)
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
정경용(Jeong, Kyoung Yong) ORCID logo https://orcid.org/0000-0001-9887-1426
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163177
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