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Sensitization to Various Minor House Dust Mite Allergens is greater in patients with Atopic Dermatitis Than in Those with Respiratory Allergic Disease

 K. H. Park  ;  J. Lee  ;  J.‐Y. Lee  ;  S. C. Lee  ;  D. W. Sim  ;  J. U. Shin  ;  C. O. Park  ;  J.‐H. Lee  ;  K. H. Lee  ;  K. Y. Jeong  ;  J.‐W. Park 
 Clinical and Experimental Allergy, Vol.48(8) : 1050-1058, 2018 
Journal Title
 Clinical and Experimental Allergy 
Issue Date
allergic rhinitis ; asthma ; atopic dermatitis ; house dust mite ; recombinant allergen
BACKGROUND: Various allergenic proteins are produced by house dust mites (HDM). However, the allergenicity and clinical implications of these allergens are unknown. OBJECTIVE: The purpose of this study was to identify allergens in Dermatophagoides farinae and elucidate the sensitization profiles to these in Korean patients suffering from respiratory (allergic rhinitis and/or asthma) and atopic dermatitis symptoms. METHODS: IgE reactivities in sera from 160 HDM allergy patients were analysed by one- and two-dimensional gel electrophoresis and immunoblotting. IgE-reactive components were identified by liquid chromatography-coupled electrospray ionization-tandem mass spectrometry. Nine recombinant mite allergens (Der f 1, Der f 2, Der f 10, Der f 11, Der f 13, Der f 14, Der f 30, Der f 32 and Der f Alt a 10) were produced, and the IgE reactivity in sera to each was determined by ELISAs. RESULTS: Der f 1 and Der f 2 were recognized by IgE in serum samples from 88.1% and 78.1% of all patients, respectively. Patients with respiratory allergies were mainly sensitized to these major allergens, whereas patients with atopic dermatitis symptoms showed polysensitization to major and minor allergen components (including Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10). CONCLUSIONS: Patients with respiratory allergic disease sensitize to major allergen components of HDM. Those with atopic dermatitis were sensitized to a broader range of minor allergen components of HDM (Der f 11, Der f 13, Der f 14, Der f 32 and Der f Alt a 10).
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소)
Yonsei Authors
박경희(Park, Kyung Hee) ; 박중원(Park, Jung Won) ; 박창욱(Park, Chang Ook) ; 신정우(Shin, Jung U) ; 이광훈(Lee, Kwang Hoon) ; 이상철(Lee, Sang Chul) ; 이재현(Lee, Jae Hyun) ; 정경용(Jeong, Kyoung Yong)
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