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Clinical Significance of Macrophage Polarization in Antibody-Mediated Rejection of Renal Allograft

 J. Kim  ;  S.-E. Choi  ;  B.J. Lim  ;  Y.S. Kim  ;  K.H. Huh  ;  J. Lee  ;  S.I. Kim  ;  M.S. Kim  ;  H.J. Jeong 
 Transplantation Proceedings, Vol.50(4) : 1005-1008, 2018 
Journal Title
 Transplantation Proceedings 
Issue Date
Adult ; Female ; Graft Rejection/immunology* ; Graft Rejection/pathology ; Graft Survival/immunology* ; Humans ; Kaplan-Meier Estimate ; Kidney Transplantation/adverse effects* ; Kidney Transplantation/methods ; Kidney Transplantation/mortality ; Macrophages/immunology* ; Macrophages/pathology ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Transplantation, Homologous
BACKGROUND: The significance of proinflammatory M1 (classically activated) and profibrotic M2 (alternatively activated) macrophages in antibody-mediated rejection (ABMR) after kidney transplantation has not been investigated. METHODS: Fifty-five biopsy-confirmed ABMR samples were stained with MRP 8/14 (a marker of M1 macrophages) and CD163 (a marker of M2 macrophages), and positive cells were counted in glomeruli and the tubulointerstitium, respectively. Patients were classified into M1 and M2 polarization groups according to the glomerular and tubulointerstitial M1:M2 ratio, and the results were compared with Banff scores, serum creatinine level, estimated glomerular filtration rate (eGFR), and graft survival. RESULTS: The glomerular M2 polarization group showed significantly higher chronic glomerulopathy scores, serum creatinine levels, and lower eGFR at the time of biopsy (P = .019 and P = .015, respectively) and 3-month postbiopsy (P = .016 and P = .032, respectively) than the M1 polarization group. The tubulointerstitial M2 polarization group had significantly lower glomerulitis, arteritis, peritubular capillaritis, and glomerulitis + peritubular capillaritis scores than the M1 polarization group, but there was no significant difference in renal function. Long-term graft survival was not associated with macrophage polarization. CONCLUSION: Glomerular M2 polarization in ABMR biopsy samples is associated with chronic glomerular injury and poorer graft function, but without graft survival.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
김지섭(Kim, Jisup) ORCID logo https://orcid.org/0000-0002-0742-5517
이주한(Lee, Ju Han)
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
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