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Elevated urinary N-Acetyl-β-D-glucosaminidase is associated with high glycoalbumin-To-hemoglobin A1c ratio in type 1 diabetes patients with early diabetic kidney disease

Authors
 Namki Hong  ;  Minyoung Lee  ;  Soyoung Park  ;  Yong-ho Lee  ;  Sang-Man Jin  ;  Jae Hyeon Kim  ;  Byung-Wan Lee 
Citation
 Scientific Reports, Vol.8(1) : 6710-6718, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
Urinary N-acetyl-β-D-glucosaminidase (uNAG) predicted the progression of diabetic kidney disease (DKD) prior to development of albuminuria in diabetes patients. We sought whether uNAG level is associated with glycoalbumin-to-hemoglobin A1c ratio (G/A ratio), a marker of postprandial hyperglycemia and glycemic excursion, independent of albuminuria and kidney function. The association between uNAG excretion and G/A ratio was assessed in 204 consecutive subjects with type 1 diabetes (T1D) (mean age 43.9 years; 49.0% men). uNAG excretion level increased along with older age, hyperglycemia, and degree of albuminuria, but was not correlated with body mass index or estimated glomerular filtration rate (eGFR). Elevated uNAG showed robust association with higher G/A ratio (adjusted β = 0.103, P = 0.020) after adjustment for age, sex, body mass index, duration of diabetes, uACR, angiotensin blockers use, fasting plasma glucose, and hemoglobin level. uNAG showed better discriminatory performance for individuals with high G/A ratio than albuminuria (AUC 0.613 vs. 0.518, P = 0.038). Measurement of uNAG improved AUC for high G/A ratio from 0.699 to 0.748 (P = 0.043) when added to conventional risk factors (cutoff 5.24 U/g creatinine; sensitivity 62.5% and specificity 58.0%). In conclusion, Elevated uNAG was found to be associated with high G/A ratio in patients with T1D with early stage DKD, independent of age and albuminuria.
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DOI
10.1038/s41598-018-25023-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
이민영(Lee, Minyoung) ORCID logo https://orcid.org/0000-0002-9333-7512
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
홍남기(Hong, Nam Ki) ORCID logo https://orcid.org/0000-0002-8246-1956
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163167
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