Cited 16 times in
Added prognostic value of CT characteristics and IASLC/ATS/ERS histologic subtype in surgically resected lung adenocarcinomas
DC Field | Value | Language |
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dc.contributor.author | 서영주 | - |
dc.date.accessioned | 2018-08-28T17:26:10Z | - |
dc.date.available | 2018-08-28T17:26:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162606 | - |
dc.description.abstract | OBJECTIVES: Our study investigates the added value of computed tomography (CT) characteristics, histologic subtype classification of the International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS), and genetic mutation for predicting postoperative prognoses of patients who received curative surgical resections for lung adenocarcinoma. MATERIALS AND METHODS: We retrospectively enrolled 988 patients who underwent curative resection for invasive lung adenocarcinoma between October 2007 and December 2013. Cox's proportional hazard model was used to explore the risk of recurrence-free survival, based on the combination of conventional prognostic factors, CT characteristics, IASLC/ATS/ERS histologic subtype, and epidermal growth factor receptor (EGFR) mutations. Incremental prognostic values of CT characteristics, histologic subtype, and EGFR mutations over conventional risk factors were measured by C-statistics. RESULTS: During median follow-up period of 44.7 months (25th to 75th percentile 24.6-59.7 months), postoperative recurrence occurred in 248 patients (25.1%). In univariate Cox proportion hazard model, female sex, tumor size and stage, CT characteristics, and predominant histologic subtype were associated with tumor recurrence (P<0.05). In multivariate Cox regression model adjusted for tumor size and stage, both CT characteristics and histologic subtype were independent tumor recurrence predictors (P<0.05). Cox proportion hazard models combining CT characteristics or histologic subtype with size and tumor stage showed higher C-indices (0.763 and 0.767, respectively) than size and stage-only models (C-index 0.759, P>0.05). CONCLUSION: CT characteristics and histologic subtype have relatively limited added prognostic values over tumor size and stage in surgically resected lung adenocarcinomas. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Added prognostic value of CT characteristics and IASLC/ATS/ERS histologic subtype in surgically resected lung adenocarcinomas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Young Joo Suh | - |
dc.contributor.googleauthor | Hyun-Ju Lee | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.contributor.googleauthor | Chang Hyun Kang | - |
dc.contributor.googleauthor | In Kyu Park | - |
dc.contributor.googleauthor | Yoon Kyung Jeon | - |
dc.contributor.googleauthor | Doo Hyun Chung | - |
dc.identifier.doi | 10.1016/j.lungcan.2018.04.007 | - |
dc.contributor.localId | A01892 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 29748007 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0169500218303349 | - |
dc.subject.keyword | CT characteristics | - |
dc.subject.keyword | EGFR mutation | - |
dc.subject.keyword | Histologic subtype | - |
dc.subject.keyword | Lung adenocarcinoma | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Suh, Young Joo | - |
dc.contributor.affiliatedAuthor | Suh, Young Joo | - |
dc.citation.volume | 120 | - |
dc.citation.startPage | 130 | - |
dc.citation.endPage | 136 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.120 : 130-136, 2018 | - |
dc.identifier.rimsid | 60186 | - |
dc.type.rims | ART | - |
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