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The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

Authors
 Hyunsung Park  ;  Jae Jun Park  ;  Yoo Mi Park  ;  Su Jung Baik  ;  Hyun Ju Lee  ;  Da Hyun Jung  ;  Jie-Hyun Kim  ;  Young Hoon Youn  ;  Hyojin Park 
Citation
 HELICOBACTER, Vol.23(3) : e12477, 2018 
Journal Title
 HELICOBACTER 
ISSN
 1083-4389 
Issue Date
2018
Keywords
Helicobacter pylori ; advanced colorectal neoplasia ; age ; smoking
Abstract
BACKGROUND: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. METHODS: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and >/=50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H. pylori immunoglobulin G or rapid urease test, if the anti-H. pylori immunoglobulin G was in the borderline range. RESULTS: Among the 19 337 patients who were included, 56.2% and 3.4% were positive for H. pylori and ACN, respectively. Helicobacter pylori infection independently increased the risk of ACN in patients aged <50 years (odds ratio [OR], 1.602; 95% confidence intervals [CI], 1.194-2.150) but not in patients aged >/=50 years (OR, 1.046; 95% CI, 0.863-1.268). The positive association between H. pylori infection and ACN was affected by smoking history. When stratified by age and smoking history, H. pylori infection conferred an increased risk of ACN in patients aged <50 years with a history of smoking (OR, 1.926; 95% CI, 1.336-2.775) but not in the other 3 groups (3-way interaction test P = .023). Among patients aged <50 years with ACN, ACN in the left colon was found more frequently in patients with H. pylori infection and a history of smoking than in those without (69.3% vs 54.4%, respectively; P = .031). CONCLUSIONS: Helicobacter pylori infection confers an increased risk of ACN, but the association may differ according to age and smoking history.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/hel.12477
DOI
10.1111/hel.12477
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Yoo Mi(박유미) ORCID logo https://orcid.org/0000-0002-3642-7300
Park, Jae Jun(박재준)
Park, Hyeun Sung(박현성)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Jung, Da Hyun(정다현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162574
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