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Effect of striatal dopamine depletion on cognition in de novo Parkinson's disease

 Seok Jong Chung  ;  Han Soo Yoo  ;  Jungsu S Oh  ;  Jae Seung Kim  ;  Byoung Seok Ye  ;  Young H Sohn  ;  Phil Hyu Lee 
 Parkinsonism & Related Disorders, Vol.51 : 43-48, 2018 
Journal Title
 Parkinsonism & Related Disorders 
Issue Date
Cognition ; Dopamine transporter ; Parkinson's disease
INTRODUCTION: To investigate the relationship between the sub-regional pattern of striatal dopamine depletion and cognitive impairment in early-stage Parkinson's disease (PD), and determine the effect of striatal dopamine density on cognitive prognosis. METHODS: Patients with drug-naive non-demented PD were divided into mild cognitive impairment (PD-MCI; n=129) and cognitively normal (PD-CogN; n=182) groups. Using quantification of the dopamine transporter (DAT) availability in each striatal sub-region with (18)F-FP-CIT PET scans, we performed inter-group comparative analysis of DAT availability and multivariate linear regression analysis to assess the association between DAT availability and cognitive performance. Additionally, the effect of baseline DAT availability on the cognitive decline across time as well as on changes in the cognitive status was estimated. RESULTS: The PD-MCI group exhibited more severely decreased DAT availability in all the striatal sub-regions compared to the PD-CogN group, although there was no significant difference in PD duration. The DAT availability in the caudate, anterior putamen, and ventral striatum was directly associated with attention/working memory, frontal/executive, and visuospatial functions, while the DAT availability of the posterior putamen was not. However, the baseline DAT availability of the striatal sub-regions did not influence the cognitive decline or cognitive status in the longitudinal cognitive assessment. CONCLUSION: Our results suggest that striatal DAT availability may determine MCI in patients with de novo PD. Dopamine loss in the associative and limbic striatum is closely linked to cognitive deficits in early-stage PD, although it does not affect cognitive prognosis.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
예병석(Ye, Byoung Seok) ORCID logo https://orcid.org/0000-0003-0187-8440
유한수(Yoo, Han Soo) ORCID logo https://orcid.org/0000-0001-7846-6271
이필휴(Lee, Phil Hyu)
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
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