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Effect of flapless osteoperforation-assisted tooth movement on atrophic alveolar ridge: Histomorphometric and gene-enrichment analysis

Authors
 Ji-Won Lee  ;  Jung-Yul Cha  ;  Ki-Ho Park  ;  Yoon-Goo Kang  ;  Su-Jung Kim 
Citation
 Angle Orthodontist, Vol.88(1) : 82-90, 2018 
Journal Title
 Angle Orthodontist 
ISSN
 0003-3219 
Issue Date
2018
Keywords
Atrophic alveolar ridge ; Flapless-osteoperforation ; Gene-enrichment analysis ; Histomorphometric analysis ; Orthodontic tooth movement
Abstract
OBJECTIVE: To investigate the effect of flapless osteoperforation on the tissue response of the atrophic alveolar ridge affected by orthodontic tooth movement (OTM). MATERIALS AND METHODS: An atrophic alveolar ridge model was established in the mandibular quadrants of eight beagle dogs. As a split-mouth design, the quadrants were randomly divided into group C (OTM only) and group OP (OTM with flapless osteoperforation). The rate of OTM for 10 weeks was compared between groups, and micro-CT-based histomorphometric analysis and RNA-sequencing-based gene-enrichment analysis were performed targeting the atrophic ridge. RESULTS: Group OP displayed more rapid tooth movement with lower bone mineral density and higher trabecular fraction in the atrophic ridge than did group C, showing no intergroup difference of total ridge volume. As contributing biological functional pathways in group OP, the genes related to osteoclast differentiation and TNF signaling pathway were up-regulated and those associated with Wnt signaling pathway and AMPK signaling pathway were down-regulated. CONCLUSIONS: Flapless osteoperforation facilitated the rate of OTM toward the atrophic ridge, maintaining low bone density, whereas it did not increase the volume of the atrophic ridge.
Full Text
http://www.angle.org/doi/10.2319/061217-388.1
DOI
10.2319/061217-388.1
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
차정열(Cha, Jung Yul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162535
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