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Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis

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dc.contributor.author강영애-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author이혜존-
dc.contributor.author조상래-
dc.date.accessioned2018-08-28T17:21:30Z-
dc.date.available2018-08-28T17:21:30Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162515-
dc.description.abstractBACKGROUND: Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) is a potential biomarker of treatment response in chronic hepatitis C virus infection and lung diseases, including tuberculosis. In this study, we assessed IP-10 levels in urine samples from patients with active TB at diagnosis, during treatment, and at completion, and compared these with levels in serum samples collected in parallel from matched patients to determine whether urine IP-10 can be used to monitor treatment response in patients with active TB. METHODS: IP-10 was measured using enzyme-linked immunosorbent assays in urine and serum samples collected concomitantly from 23 patients with active TB and 21 healthy adults (44 total individuals). The Mann-Whitney U test and Wilcoxon matched-pairs signed rank test were used for comparisons among healthy controls and patients at three time points, and LOESS regression was used for longitudinal data. RESULTS: The levels of IP-10 in urine increased significantly after 2 months of treatment (P = 0.0163), but decreased by the completion of treatment (P = 0.0035). Serum IP-10 levels exhibited a similar trend, but did not increase significantly after 2 months of treatment in patients with active TB. CONCLUSIONS: Unstimulated IP-10 in urine can be used as a biomarker to monitor treatment response in patients with active pulmonary TB.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC Infectious Diseases-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUrine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorJungho Kim-
dc.contributor.googleauthorDeok Ryun Kim-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorSungyoung Bong-
dc.contributor.googleauthorJonghee Lee-
dc.contributor.googleauthorSuyeon Kim-
dc.contributor.googleauthorNam Suk Lee-
dc.contributor.googleauthorBora Sim-
dc.contributor.googleauthorSang-Nae Cho-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorHyejon Lee-
dc.identifier.doi10.1186/s12879-018-3144-3-
dc.contributor.localIdA00057-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA04865-
dc.contributor.localIdA03824-
dc.relation.journalcodeJ00360-
dc.identifier.eissn1471-2334-
dc.identifier.pmid29843631-
dc.subject.keywordBiomarker-
dc.subject.keywordMonitoring-
dc.subject.keywordTuberculosis-
dc.subject.keywordUrine IP-10-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameLee, Hyejon-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorLee, Hyejon-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage240-
dc.identifier.bibliographicCitationBMC Infectious Diseases, Vol.18(1) : 240, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Immunology and Immunological Disease (면역질환연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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