0 34

Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study

Authors
 Taeryool Koo  ;  Do Hoon Lim  ;  Ho Jun Seol  ;  Chul-Kee Park  ;  Il Han Kim  ;  Jong Hee Chang  ;  Jeongshim Lee  ;  Shin Jung  ;  Ho-Shin Gwak  ;  Kwan Ho Cho  ;  Chang-Ki Hong  ;  Ik Jae Lee  ;  El Kim  ;  Jin Hee Kim  ;  Yong-Kil Hong  ;  Hong Seok Jang  ;  Chae-Yong Kim  ;  In Ah Kim  ;  Sung Hwan Kim  ;  Young Il Kim  ;  Eun-Young Kim  ;  Woo Chul Kim  ;  Semie Hong 
Citation
 Journal of Neuro-Oncology, Vol.138(3) : 667-677, 2018 
Journal Title
 Journal of Neuro-Oncology 
ISSN
 0167-594X 
Issue Date
2018
Keywords
Low-grade glioma ; PCV ; Patterns of care ; Radiotherapy ; Temozolomide
Abstract
INTRODUCTION: We performed this study to identify the treatment patterns of patients with low-grade gliomas (LGG) in Korea. METHODS: A total of 555 patients diagnosed as WHO grade II gliomas between 2000 and 2010 at 14 Korean institutions were included. The patients were divided into four adjuvant treatment groups: adjuvant fractionated radiotherapy (RT, N = 204), adjuvant chemotherapy (N = 20), adjuvant fractionated RT and chemotherapy (N = 65), and non-adjuvant treatment (N = 266) groups. We examined differences among the groups and validated patient/tumor characteristics associated with the adjuvant treatments. RESULTS: Astrocytoma was diagnosed in 210 patients (38%), oligoastrocytoma in 85 patients (15%), and oligodendroglioma in 260 patients (47%). Gross total resection was performed in 200 patients (36%), subtotal resection in 153 (28%), partial resection in 71 patients (13%), and biopsy in 131 patients (24%). RT was most commonly applied as an adjuvant treatment. The use of chemotherapy with or without RT decreased after 2008 (from 38 to 4%). The major chemotherapeutic regimen was procarbazine, lomustine, and vincristine (PCV); however, the proportion of temozolomide increased since 2005 (up to 69%). Patient/tumor characteristics related with RT were male gender, non-seizure, multiple lobes involvement, and non-gross total resection. Chemotherapy was associated with non-gross total resection and non-astrocytoma. CONCLUSIONS: A preference for RT and increased use of temozolomide was evident in the treatment pattern of LGG. The extent of resection was associated with a decision to perform RT and chemotherapy. To establish a robust guideline for LGG, further studies including molecular information are needed.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162504
Full Text
https://link.springer.com/article/10.1007%2Fs11060-018-2839-z
DOI
10.1007/s11060-018-2839-z
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
이익재(Lee, Ik Jae) ORCID logo https://orcid.org/0000-0001-7165-3373
이정심(Lee, Jeong Shim)
장종희(Chang, Jong Hee)
홍창기(Hong, Chang Ki)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse