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Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study
DC Field | Value | Language |
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dc.contributor.author | 이익재 | - |
dc.contributor.author | 이정심 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 홍창기 | - |
dc.date.accessioned | 2018-08-28T17:21:04Z | - |
dc.date.available | 2018-08-28T17:21:04Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162504 | - |
dc.description.abstract | INTRODUCTION: We performed this study to identify the treatment patterns of patients with low-grade gliomas (LGG) in Korea. METHODS: A total of 555 patients diagnosed as WHO grade II gliomas between 2000 and 2010 at 14 Korean institutions were included. The patients were divided into four adjuvant treatment groups: adjuvant fractionated radiotherapy (RT, N = 204), adjuvant chemotherapy (N = 20), adjuvant fractionated RT and chemotherapy (N = 65), and non-adjuvant treatment (N = 266) groups. We examined differences among the groups and validated patient/tumor characteristics associated with the adjuvant treatments. RESULTS: Astrocytoma was diagnosed in 210 patients (38%), oligoastrocytoma in 85 patients (15%), and oligodendroglioma in 260 patients (47%). Gross total resection was performed in 200 patients (36%), subtotal resection in 153 (28%), partial resection in 71 patients (13%), and biopsy in 131 patients (24%). RT was most commonly applied as an adjuvant treatment. The use of chemotherapy with or without RT decreased after 2008 (from 38 to 4%). The major chemotherapeutic regimen was procarbazine, lomustine, and vincristine (PCV); however, the proportion of temozolomide increased since 2005 (up to 69%). Patient/tumor characteristics related with RT were male gender, non-seizure, multiple lobes involvement, and non-gross total resection. Chemotherapy was associated with non-gross total resection and non-astrocytoma. CONCLUSIONS: A preference for RT and increased use of temozolomide was evident in the treatment pattern of LGG. The extent of resection was associated with a decision to perform RT and chemotherapy. To establish a robust guideline for LGG, further studies including molecular information are needed. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Taeryool Koo | - |
dc.contributor.googleauthor | Do Hoon Lim | - |
dc.contributor.googleauthor | Ho Jun Seol | - |
dc.contributor.googleauthor | Chul-Kee Park | - |
dc.contributor.googleauthor | Il Han Kim | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Jeongshim Lee | - |
dc.contributor.googleauthor | Shin Jung | - |
dc.contributor.googleauthor | Ho-Shin Gwak | - |
dc.contributor.googleauthor | Kwan Ho Cho | - |
dc.contributor.googleauthor | Chang-Ki Hong | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | El Kim | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Yong-Kil Hong | - |
dc.contributor.googleauthor | Hong Seok Jang | - |
dc.contributor.googleauthor | Chae-Yong Kim | - |
dc.contributor.googleauthor | In Ah Kim | - |
dc.contributor.googleauthor | Sung Hwan Kim | - |
dc.contributor.googleauthor | Young Il Kim | - |
dc.contributor.googleauthor | Eun-Young Kim | - |
dc.contributor.googleauthor | Woo Chul Kim | - |
dc.contributor.googleauthor | Semie Hong | - |
dc.identifier.doi | 10.1007/s11060-018-2839-z | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A03112 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A04445 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 29572674 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs11060-018-2839-z | - |
dc.subject.keyword | Low-grade glioma | - |
dc.subject.keyword | PCV | - |
dc.subject.keyword | Patterns of care | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Temozolomide | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Lee, Jeong Shim | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.alternativeName | Hong, Chang Ki | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Shim | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Hong, Chang Ki | - |
dc.citation.volume | 138 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 667 | - |
dc.citation.endPage | 677 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.138(3) : 667-677, 2018 | - |
dc.identifier.rimsid | 60085 | - |
dc.type.rims | ART | - |
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