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Nitric Oxide, an Old Molecule With Noble Functions in Pseudomonas aeruginosa Biology

Authors
 Masanori Toyofuku  ;  Sang-Sun Yoon 
Citation
 Advances in Microbial Physiology, Vol.72 : 117-145, 2018 
Journal Title
 Advances in Microbial Physiology 
ISSN
 0065-2911 
Issue Date
2018
Keywords
Anaerobic respiration ; Biofilm formation ; Cell elongation ; Membrane vesicle ; Nitric oxide ; Pseudomonas aeruginosa
Abstract
Pseudomonas aeruginosa, a Gram-negative bacterium, is characterized by its versatility that enables persistent survival under adverse conditions. It can grow on diverse energy sources and readily acquire resistance to antimicrobial agents. As an opportunistic human pathogen, it also causes chronic infections inside the anaerobic mucus airways of cystic fibrosis patients. As a strict respirer, P. aeruginosa can grow by anaerobic nitrate ( [Formula: see text] ) respiration. Nitric oxide (NO) produced as an intermediate during anaerobic respiration exerts many important effects on the biological characteristics of P. aeruginosa. This review provides information regarding (i) how P. aeruginosa grows by anaerobic respiration, (ii) mechanisms by which NO is produced under such growth, and (iii) bacterial adaptation to NO. We also review the clinical relevance of NO in the fitness of P. aeruginosa and the use of NO as a potential therapeutic for treating P. aeruginosa infection.
Full Text
https://www.sciencedirect.com/science/article/pii/S0065291118300055
DOI
10.1016/bs.ampbs.2018.01.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162461
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