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Cancer development in Korean patients with ANCA-associated vasculitis: a single centre study

Authors
 Juyoung Yoo  ;  Sung Soo Ahn  ;  Seung Min Jung  ;  Jason Jungsik Song  ;  Yong-Beom Park  ;  Sang-Won Lee 
Citation
 Clinical and Experimental Rheumatology, Vol.36 Suppl 111(2) : 73-77, 2018 
Journal Title
 Clinical and Experimental Rheumatology 
ISSN
 0392-856X 
Issue Date
2018
Abstract
OBJECTIVES: We investigated the incidence rate and type of cancer, and furthermore, estimated the standardised incidence ratios (SIRs) of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Korea. METHODS: We retrospectively included 150 patients with AAV [81 patients with microscopic polyangiitis (MPA), 38 with granulomatosis with polyangiitis (GPA) and 31 patients with eosinophilic GPA (EGPA)], and reviewed their medical records. We collected demographic, clinical and laboratory data, and reviewed the use of glucocorticoid and immunosuppressive drugs administered until detection of cancer or last visit. We estimated the SIRs of cancer according to totality, gender, age, AAV variants and each type of cancer. RESULTS: The mean age at diagnosis of AAV was 55.2 years and that at last visit was 59.5 years. The mean follow-up duration was 50.7 months. Four of 150 AAV patients had cancer (2.7%), and they got four different types of cancers including gastric cancer, lung cancer, prostate cancer and Non-Hodgkin lymphoma. Two patients exhibited gap-time from AAV to malignancy less than one year, and the rest of them exhibited gap-time of 8 and 6 years, respectively. The overall SIR of cancer in AAV patients was 1.43 (95% confidence interval 0.391, 3.671). The SIRs of cancer based on gender, and age at cancer or last visit, AAV variants and each type of cancer were not significant, either. CONCLUSIONS: The risk of cancer is low in Korean patients with AAV.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162456
Full Text
http://www.clinexprheumatol.org/abstract.asp?a=12413
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박용범(Park, Yong Beom)
송정식(Song, Jung Sik)
안성수(Ahn, Sung Soo) ORCID logo https://orcid.org/0000-0002-9002-9880
유주영(Yoo, Juyoung)
이상원(Lee, Sang Won)
정승민(Jung, Seung Min )
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