198 57

Cited 1 times in

The cholinergic contribution to the resting-state functional network in non-demented Parkinson's disease

 Yoonju Lee  ;  Jee Hyun Ham  ;  Jungho Cha  ;  Yeong-Hun Park  ;  Jae Jung Lee  ;  Mun Kyung Sunwoo  ;  Jin Yong Hong  ;  Young H Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
 Scientific Reports, Vol.8(1) : 7683, 2018 
Journal Title
 Scientific Reports 
Issue Date
The cholinergic system arising from the basal forebrain plays an important role in cognitive performance in Parkinson's disease (PD). Here, we analyzed cholinergic status-dependent cortical and subcortical resting-state functional connectivity in PD. A total of 61 drug-naive PD patients were divided into tertiles based on normalized substantia innominata (SI) volumes. We compared the resting-state network from seed region of interest in the caudate, posterior cingulate cortex (PCC), and SI between the lowest (PD-L) and highest tertile (PD-H) groups. Correlation analysis of the functional networks was also performed in all subjects. The functional network analysis showed that PD-L subjects displayed decreased striato-cortical functional connectivity compared with PD-H subjects. Selecting the PCC as a seed, the PD-L patients displayed decreased functional connectivity compared to PD-H patients. Meanwhile, PD-L subjects had significantly increased cortical functional connectivity with the SI compared with PD-H subjects. Correlation analysis revealed that SI volume had a positive correlation with functional connectivity from the right caudate and PCC. The present study demonstrated that PD patients exhibited unique functional connectivity from the caudate and the PCC that may be closely associated with cholinergic status, suggesting an important role for the cholinergic system in PD-associated cognition.
Files in This Item:
T201801573.pdf Download
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
이윤주(Lee, Yoon Ju)
이필휴(Lee, Phil Hyu)
함지현(Ham, Jee Hyun)
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.