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Randomized controlled trial of steroid-soaked absorbable calcium alginate nasal packing following endoscopic sinus surgery

Authors
 Chi Sang Hwang  ;  Salma Saud Al Sharhan  ;  Bo Ra Kim  ;  Soo In Kim  ;  Jin Woong Kim  ;  Hyung-Ju Cho  ;  Joo-Heon Yoon  ;  Chang-Hoon Kim 
Citation
 Laryngoscope, Vol.128(2) : 311-316, 2018 
Journal Title
 Laryngoscope 
ISSN
 0023-852X 
Issue Date
2018
Keywords
Endoscopic sinus surgery ; nasal packing ; nasal polyps ; surgical outcomes ; triamcinolone
Abstract
OBJECTIVES/HYPOTHESIS: To evaluate the potential efficacy of steroid-soaked, absorbable calcium alginate nasal packing following endoscopic sinus surgery. STUDY DESIGN: Prospective, randomized, single-blinded, placebo-controlled trial. METHODS: Twenty-two patients (44 nostrils) who had chronic rhinosinusitis with polyps underwent bilateral endoscopic sinus surgery. Only those with an intersinus difference in Lund-Mackay severity score of 1 or less were included. In each patient, one randomly selected nostril was packed with calcium alginate soaked with 2 mL of triamcinolone (40 mg/mL) (triamcinolone group), whereas the contralateral nostril received an identical packing soaked in 2 mL of normal saline (saline group). Two independent investigators blinded to the packing allocation scored the surgical field using the validated Perioperative Sinus Endoscopy (POSE) scores 1, 4, and 8 weeks after surgery. RESULTS: All 44 nostrils were analyzed; the Lund-Mackay scores did not differ significantly between the groups before surgery. Eight weeks after surgery, the total POSE scores were significantly lower in the triamcinolone group (P = .014). The POSE scoring parameters were then compared between groups, and the following variables were significantly different: middle turbinate synechiae with the lateral wall (P = .037), polypoid degeneration of the ethmoid cavity (P = .006), and sphenoid sinus severity (P = .036). CONCLUSIONS: This study demonstrated that steroid-soaked, absorbable nasal packing can be used to enhance wound healing after endoscopic sinus surgery and to prevent polypoid changes in the nasal mucosa. LEVEL OF EVIDENCE: 1b. Laryngoscope, 128:311-316, 2018.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162415
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.26871
DOI
10.1002/lary.26871
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
Yonsei Authors
김창훈(Kim, Chang Hoon)
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