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Association between thyroid hormones and the components of metabolic syndrome

 Jieun Jang  ;  Youngsook Kim  ;  Jaeyong Shin  ;  Sang Ah Lee  ;  Young Choi  ;  Eun-Cheol Park 
 BMC ENDOCRINE DISORDERS, Vol.18(1) : 29, 2018 
Journal Title
Issue Date
FT4 ; Free thyroxine ; Metabolic syndrome ; Thyroid hormone
BACKGROUND: Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. METHODS: The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015. A total of 1423 participants were tested for thyroid function. The analysis of variance and multiple linear regression were performed to analyze the relationship between thyroid hormone level and components of the metabolic syndrome. RESULTS: A positive association between free thyroxine and fasting glucose level was observed in patients with high free thyroxine levels (>/=1.70 ng/dL, beta = 15.992, p = < 0.0001), when compared with patients with normal-middle free thyroxine levels. Moreover, a negative association was observed between free thyroxine and triglyceride levels in patients with normal-high free thyroxine levels (beta = - 21.145, p = 0.0054) and those with high free thyroxine levels (beta = - 49.713, p = 0.0404). CONCLUSION: Free thyroxine shows a partially positive association with fasting glucose and a partially negative association with triglycerides in the Korean population. In patients with abnormal thyroid function, follow up tests for glucose levels and lipid profiling during treatment for thyroid dysfunction would be beneficial in terms of overlooking metabolic syndrome and to prevent related diseases.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Sook(김영숙)
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Shin, Jae Yong(신재용)
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