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Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds

Authors
 Jeong Eun Shin  ;  Kwangsoo Jung  ;  Miri Kim  ;  Kyujin Hwang  ;  Haejin Lee  ;  Il-Sun Kim  ;  Bae Hwan Lee  ;  Il-Shin Lee  ;  Kook In Park 
Citation
 Experimental and Molecular Medicine, Vol.50(4) : 39, 2018 
Journal Title
 Experimental and Molecular Medicine 
ISSN
 1226-3613 
Issue Date
2018
Abstract
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI. Implantation of human NPC (hNPC)-scaffold complex reduced the lesion volume, induced survival, engraftment, and differentiation of grafted cells, increased neovascularization, inhibited glial scar formation, altered the microglial/macrophage response, promoted neurite outgrowth and axonal extension within the lesion site, and facilitated the connection of damaged neural circuits. Tract tracing demonstrated that hNPC-scaffold grafts appear to reform the connections between neurons and their targets in both cerebral hemispheres in HI brain injury and protect some injured corticospinal fibers in SCI. Finally, the hNPC-scaffold complex grafts significantly improved motosensory function and attenuated neuropathic pain over that of the controls. These findings suggest that, with further investigation, this optimized multidisciplinary approach of combining hNPCs with biomaterial scaffolds provides a more versatile treatment for brain injury and SCI.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162406
Files in This Item:
T201801521.pdf Download
DOI
10.1038/s12276-018-0054-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
Yonsei Authors
김일선(Kim, Il-Sun) ORCID logo https://orcid.org/0000-0003-4033-4323
박국인(Park, Kook In) ORCID logo https://orcid.org/0000-0001-8499-9293
신정은(Shin, Jeong Eun) ORCID logo https://orcid.org/0000-0002-4376-8541
이배환(Lee, Bae Hwan)
황규진(Hwang, Kyujin) ORCID logo https://orcid.org/0000-0001-5193-5154
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