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Disruption of the Gut Ecosystem by Antibiotics

Authors
 Mi Young Yoon  ;  Sang Sun Yoon 
Citation
 Yonsei Medical Journal, Vol.59(1) : 43202, 2018 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2018
MeSH
Anti-Bacterial Agents/*pharmacology ; Bacteria/drug effects/growth & development ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/*drug effects ; Humans ; Intestines/drug effects/microbiology ; Symbiosis/drug effects
Keywords
Microbiota ; antibiotics ; enteric pathogen ; fecal microbiota transplantation (FMT) ; probiotics
Abstract
The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory diseases. Here, we illustrate how antibiotics are associated with an increased risk of antibiotic-associated diseases by driving intestinal environment changes that favor the proliferation and virulence of pathogens. Understanding the pathogenesis caused by antibiotics would be a crucial key to the treatment of antibiotic-associated diseases by mitigating changes in the intestinal environment and restoring it to its original state.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162393
Files in This Item:
T201801502.pdf Download
DOI
10.3349/ymj.2018.59.1.4
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실)
Yonsei Authors
윤상선(Yoon, Sang Sun)
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