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Off-Clamp Robot-Assisted Partial Nephrectomy: How Far Shall We Proceed?

 Ali Abdel Raheem  ;  Glen Denmer Santok  ;  Lawrence H C Kim  ;  Ki Don Chang  ;  Trenton G H Lum  ;  Young Eun Yoon  ;  Woong Kyu Han  ;  Young Deuk Choi  ;  Koon Ho Rha 
 Journal of Laparoendoscopic & Advanced Surgical Techniques, Vol.28(5) : 579-585, 2018 
Journal Title
 Journal of Laparoendoscopic & Advanced Surgical Techniques 
Issue Date
off-clamp ; partial nephrectomy ; renal tumor ; robotics ; urology
BACKGROUND: Off-clamp robot-assisted partial nephrectomy (RAPN) is associated with increased intraoperative blood loss compared with on-clamp technique. Our aim was to demonstrate our surgical technique and to determine which tumors are ideally suited for this technique. METHODS: Sixty-two patients who underwent off-clamp RAPN for renal tumor between 2006 and 2016 were retrospectively analyzed. Increased estimated blood loss (EBL) volume was defined as more than 75 percentile. receiver operating characteristic (ROC) analysis was used to determine exact cut-off tumor size and the preoperative aspects and dimensions used for an anatomical (PADUA) score that are associated with increased EBL. Risk factors for increased EBL >400 mL and chronic kidney disease (CKD) upstaging were evaluated using logistic regression analysis. RESULTS: The median follow-up period was 20 months (interquartile range [IQR]: 12-84). Patient's mean age, mean tumor size, and mean body mass index were 53.5 +/- 12.2 years, 2.6 +/- 1.5 cm, and 25 +/- 4.1 kg/m(2), respectively. Median EBL volume was 200 mL (IQR: 100-400). ROC analysis showed that tumor size of 3.2 cm (area under the curve [AUC] = 0.82, P < .001) and PADUA score of 9 (AUC = 0.79, P = .001) were cut-off values for increased EBL >400 mL. Patients with tumor size >3.2 cm had longer operative time (116 versus 163 minutes, P = .002), more EBL (150 versus 575 mL, P < .001), and higher blood transfusion rate (0% versus 18.8%, P = .015), with increased tendency of conversion to radical nephrectomy (0% versus 12.5%, P = .063) compared with tumor size </=3.2 cm. Overall CKD upstaging was present in 22 patients (35.4%). Multivariable logistic regression analysis showed that EBL >400 mL was the only predictor of CKD upstaging (odds ratio: 6.704, P = .009). CONCLUSIONS: Our study showed that the risk of intraoperative bleeding and transfusion rate during off-clamp RAPN is increased if tumor size >3.2 cm and/or PADUA complexity score >/=9. Moreover, EBL >400 mL was a risk factor of CKD upstaging, despite zero ischemia. Further larger prospective studies are warranted to validate our results.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
나군호(Rha, Koon Ho) ORCID logo https://orcid.org/0000-0001-8588-7584
알리압델(Raheem, Ali Abdel)
윤영은(Yoon, Young Eun)
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
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