0 93

Cited 0 times in

Impact of Cigarette Smoking on Living Kidney Donors

Authors
 Y E Yoon  ;  H H Lee  ;  J C Na  ;  K H Huh  ;  M S Kim  ;  S I Kim  ;  Y S Kim  ;  W K Han 
Citation
 Transplantation Proceedings, Vol.50(4) : 1029-1033, 2018 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2018
Abstract
BACKGROUND: Smoking is known to result in a decline in renal allograft function and survival of recipients; however, the effect of smoking on living kidney donors remains unknown. In this study we evaluated the impact of cigarette smoking on renal function of kidney donors. METHODS: Among 1056 donors who underwent nephrectomy, 612 completed the 6-month follow-up protocol and were enrolled in the study. The association of smoking status, including pack-years smoking history, and postoperative renal function was evaluated. RESULTS: Among donors, 68.1% had never smoked, 8% were former smokers, and 23.9% were current smokers. Donors who never smoked were older than former and current smokers (42.3 +/- 11.8, 41.9 +/- 11.1, and 38.3 +/- 10.9 years, respectively; P < .001). There was no difference in preoperative renal function between groups; however, postoperative estimated glomerular filtration rate (eGFR) was lower in former and current smokers than in those who never smoked (64.6 +/- 13.8, 64.7 +/- 12.3, and 67.8 +/- 13.1 mL/min/1.73 m(2), respectively; P = .023). In former and current smokers, pack-years smoking history was negatively associated with pre- and postoperative eGFR (r = -0.305 and -0.435, P < .001), and correlated with postoperative percent eGFR decline (r = 0.248, P < .001). Smoking history was associated with postoperative development of chronic kidney disease (CKD). Especially in former smokers, a smoking history of more than 12 pack-years was strongly associated with development of CKD (odds ratio = 7.5, P = .003). CONCLUSION: Even if they no longer smoke, donors with a smoking history require close observation due to increased risk of CKD development after kidney donation. A detailed pack-years smoking history should be obtained, and smoking cessation strategies should be implemented in kidney donors.
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134518301386
DOI
10.1016/j.transproceed.2018.02.050
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
나준채(Na, Joon Chae) ORCID logo https://orcid.org/0000-0003-4449-8472
윤영은(Yoon, Young Eun)
이형호(Lee, Hyung Ho)
한웅규(Han, Woong Kyu) ORCID logo https://orcid.org/0000-0002-2527-4046
허규하(Huh, Kyu Ha) ORCID logo https://orcid.org/0000-0003-1364-6989
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162356
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse