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Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma

Authors
 Jin Woo Joo  ;  Hyun-Soo Kim  ;  Sung-Im Do  ;  Ji-Youn Sung 
Citation
 Anticancer Research, Vol.38(5) : 2787-2792, 2018 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2018
MeSH
Tumor/*analysis Biomarkers ; Tumor Cell Line ; Colorectal Neoplasms/metabolism/*pathology ; DNA-Binding Proteins/*biosynthesis ; Humans ; Transcription Factors/*biosynthesis ; Up-Regulation
Keywords
Colon ; colorectal carcinoma ; leukemia/lymphoma-related factor ; poxvirus and zinc finger and Kruppel erythroid myeloid ontogenic factor ; zinc finger and BTB domain-containing 7A
Abstract
BACKGROUND/AIM: Previous studies have revealed that zinc finger and BTB domain-containing 7A (ZBTB7A), an important proto-oncogene, plays multiple roles in carcinogenesis and is up-regulated in several human malignancies. However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differential expression of ZBTB7A in CRC cell lines and tissues. MATERIALS AND METHODS: Expression levels of ZBTB7A mRNA and protein were examined in CRC cell lines. ZBTB7A protein expression was also evaluated in tissue samples of normal colonic mucosa, high-grade dysplasia, and CRC using immunohistochemical staining. RESULTS: All CRC cell lines exhibited significantly higher ZBTB7A mRNA expression levels than did normal colonic epithelial cells. The ZBTB7A protein expression levels were clearly higher in the CRC cell lines than in the normal colonic epithelial cells. Consistent with the cell line data, immunostaining revealed that there were significant differences in ZBTB7A protein expression between tissue samples of CRC and normal colonic mucosa (p=0.048) and high-grade dysplasia (p=0.015). In addition, metastatic CRC exhibited significantly higher ZBTB7A protein expression levels than primary CRC (p=0.027). CONCLUSION: We demonstrated that ZBTB7A expression is up-regulated in CRC cell lines and tissues. Our data suggest that ZBTB7A is involved in the development and progression of CRC.
Full Text
http://ar.iiarjournals.org/content/38/5/2787.abstract
DOI
10.21873/anticanres.12522
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김현수(Kim, Hyun-Soo)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162307
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