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Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma

DC FieldValueLanguage
dc.contributor.author김현수-
dc.date.accessioned2018-08-28T17:08:53Z-
dc.date.available2018-08-28T17:08:53Z-
dc.date.issued2018-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162307-
dc.description.abstractBACKGROUND/AIM: Previous studies have revealed that zinc finger and BTB domain-containing 7A (ZBTB7A), an important proto-oncogene, plays multiple roles in carcinogenesis and is up-regulated in several human malignancies. However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differential expression of ZBTB7A in CRC cell lines and tissues. MATERIALS AND METHODS: Expression levels of ZBTB7A mRNA and protein were examined in CRC cell lines. ZBTB7A protein expression was also evaluated in tissue samples of normal colonic mucosa, high-grade dysplasia, and CRC using immunohistochemical staining. RESULTS: All CRC cell lines exhibited significantly higher ZBTB7A mRNA expression levels than did normal colonic epithelial cells. The ZBTB7A protein expression levels were clearly higher in the CRC cell lines than in the normal colonic epithelial cells. Consistent with the cell line data, immunostaining revealed that there were significant differences in ZBTB7A protein expression between tissue samples of CRC and normal colonic mucosa (p=0.048) and high-grade dysplasia (p=0.015). In addition, metastatic CRC exhibited significantly higher ZBTB7A protein expression levels than primary CRC (p=0.027). CONCLUSION: We demonstrated that ZBTB7A expression is up-regulated in CRC cell lines and tissues. Our data suggest that ZBTB7A is involved in the development and progression of CRC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfAnticancer Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHTumor/*analysis Biomarkers-
dc.subject.MESHTumor Cell Line-
dc.subject.MESHColorectal Neoplasms/metabolism/*pathology-
dc.subject.MESHDNA-Binding Proteins/*biosynthesis-
dc.subject.MESHHumans-
dc.subject.MESHTranscription Factors/*biosynthesis-
dc.subject.MESHUp-Regulation-
dc.titleExpression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJin Woo Joo-
dc.contributor.googleauthorHyun-Soo Kim-
dc.contributor.googleauthorSung-Im Do-
dc.contributor.googleauthorJi-Youn Sung-
dc.identifier.doi10.21873/anticanres.12522-
dc.contributor.localIdA01114-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid29715100-
dc.identifier.urlhttp://ar.iiarjournals.org/content/38/5/2787.abstract-
dc.subject.keywordColon-
dc.subject.keywordcolorectal carcinoma-
dc.subject.keywordleukemia/lymphoma-related factor-
dc.subject.keywordpoxvirus and zinc finger and Kruppel erythroid myeloid ontogenic factor-
dc.subject.keywordzinc finger and BTB domain-containing 7A-
dc.contributor.alternativeNameKim, Hyun-Soo-
dc.contributor.affiliatedAuthorKim, Hyun-Soo-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage2787-
dc.citation.endPage2792-
dc.identifier.bibliographicCitationAnticancer Research, Vol.38(5) : 2787-2792, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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