0 81

Cited 1 times in

Clinicopathological Characteristics of High-grade Squamous Intraepithelial Lesions Involving Condyloma Acuminatum

Authors
 Kiyong Na  ;  Ji-Youn Sung  ;  Hyun-Soo Kim 
Citation
 Anticancer Research, Vol.38(3) : 1767-1774, 2018 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2018
MeSH
Adult ; Aged ; Anus Neoplasms/complications/*pathology ; Squamous Cell/complications/*pathology Carcinoma ; Condylomata Acuminata/complications/*pathology/virology ; Cyclin-Dependent Kinase Inhibitor p16/analysis ; Female ; Genotype ; HIV Infections/complications/pathology/virology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Papillomaviridae/genetics/physiology ; Squamous Intraepithelial Lesions of the Cervix/complications/metabolism/*pathology
Keywords
High-grade squamous intraepithelial lesion ; condyloma acuminatum ; human immunodeficiency virus ; human papillomavirus ; p16
Abstract
BACKGROUND/AIM: Severe nuclear atypia can be associated with condyloma acuminatum. In this study, we investigated nine cases of perianal condyloma acuminatum with severe nuclear atypia and determined whether severe nuclear atypia is sufficient for the diagnosis of high-grade squamous intraepithelial lesion (HSIL). MATERIALS AND METHODS: The clinical data and pathological features of the nine patients were collected. p16 Immunostaining and human papillomavirus genotyping were also performed. RESULTS: The resected specimens of six men infected with human immunodeficiency virus showed features suggestive of HSIL, including the expansion of basaloid cells, severe nuclear pleomorphism in the lower one-third, bizarre nuclei, mitotic figure in the upper two-thirds, atypical mitosis, block positivity for p16, and high-risk human papillomavirus infection. In contrast, the resected specimens of the remaining three patients did not show any of those HSIL features, even though there were several microscopic foci showing severe nuclear atypia in the upper two-thirds of the papillomatous epithelium. CONCLUSION: Our observation regarding the occurrence of HSIL involving perianal condyloma acuminatum in human immunodeficiency virus-infected patients suggests that active, complete surgical excision of perianal condyloma acuminatum and a thorough histopathological examination are necessary. The diagnosis of severe nuclear atypia involving the upper two-thirds of the epithelium should be made with great caution.
Full Text
http://ar.iiarjournals.org/content/38/3/1767.abstract
DOI
10.21873/anticanres.12414
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김현수(Kim, Hyun-Soo)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162302
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse