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Clinicopathological Characteristics of High-grade Squamous Intraepithelial Lesions Involving Condyloma Acuminatum

DC FieldValueLanguage
dc.contributor.author김현수-
dc.date.accessioned2018-08-28T17:08:40Z-
dc.date.available2018-08-28T17:08:40Z-
dc.date.issued2018-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162302-
dc.description.abstractBACKGROUND/AIM: Severe nuclear atypia can be associated with condyloma acuminatum. In this study, we investigated nine cases of perianal condyloma acuminatum with severe nuclear atypia and determined whether severe nuclear atypia is sufficient for the diagnosis of high-grade squamous intraepithelial lesion (HSIL). MATERIALS AND METHODS: The clinical data and pathological features of the nine patients were collected. p16 Immunostaining and human papillomavirus genotyping were also performed. RESULTS: The resected specimens of six men infected with human immunodeficiency virus showed features suggestive of HSIL, including the expansion of basaloid cells, severe nuclear pleomorphism in the lower one-third, bizarre nuclei, mitotic figure in the upper two-thirds, atypical mitosis, block positivity for p16, and high-risk human papillomavirus infection. In contrast, the resected specimens of the remaining three patients did not show any of those HSIL features, even though there were several microscopic foci showing severe nuclear atypia in the upper two-thirds of the papillomatous epithelium. CONCLUSION: Our observation regarding the occurrence of HSIL involving perianal condyloma acuminatum in human immunodeficiency virus-infected patients suggests that active, complete surgical excision of perianal condyloma acuminatum and a thorough histopathological examination are necessary. The diagnosis of severe nuclear atypia involving the upper two-thirds of the epithelium should be made with great caution.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfAnticancer Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnus Neoplasms/complications/*pathology-
dc.subject.MESHSquamous Cell/complications/*pathology Carcinoma-
dc.subject.MESHCondylomata Acuminata/complications/*pathology/virology-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p16/analysis-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHIV Infections/complications/pathology/virology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPapillomaviridae/genetics/physiology-
dc.subject.MESHSquamous Intraepithelial Lesions of the Cervix/complications/metabolism/*pathology-
dc.titleClinicopathological Characteristics of High-grade Squamous Intraepithelial Lesions Involving Condyloma Acuminatum-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorKiyong Na-
dc.contributor.googleauthorJi-Youn Sung-
dc.contributor.googleauthorHyun-Soo Kim-
dc.identifier.doi10.21873/anticanres.12414-
dc.contributor.localIdA01114-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid29491115-
dc.identifier.urlhttp://ar.iiarjournals.org/content/38/3/1767.abstract-
dc.subject.keywordHigh-grade squamous intraepithelial lesion-
dc.subject.keywordcondyloma acuminatum-
dc.subject.keywordhuman immunodeficiency virus-
dc.subject.keywordhuman papillomavirus-
dc.subject.keywordp16-
dc.contributor.alternativeNameKim, Hyun-Soo-
dc.contributor.affiliatedAuthorKim, Hyun-Soo-
dc.citation.volume38-
dc.citation.number3-
dc.citation.startPage1767-
dc.citation.endPage1774-
dc.identifier.bibliographicCitationAnticancer Research, Vol.38(3) : 1767-1774, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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