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Predominant subcortical accumulation of (18)F-flortaucipir binding in behavioral variant frontotemporal dementia

Authors
 Hanna Cho  ;  Sang Won Seo  ;  Jae Yong Choi  ;  Hye Sun Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Duk L Na  ;  Hee Jin Kim  ;  Chul Hyoung Lyoo 
Citation
 Neurobiology of Aging, Vol.66 : 112-121, 2018 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2018
Keywords
(18)F-flortaucipir ; Behavioral variant frontotemporal dementia ; Positron emission tomography ; Tau
Abstract
Behavioral variant frontotemporal dementia (bvFTD) is the most common form of frontotemporal dementia, and tau pathology can be found in 40%-50% of bvFTD patients. In this study, we sought to investigate (18)F-flortaucipir-binding patterns and their correlates in clinically diagnosed bvFTD patients by comparing with results for Alzheimer's disease (AD) patients. We enrolled 20 bvFTD, 20 AD, and 20 age-matched healthy subjects who underwent neuropsychological tests, magnetic resonance imaging, and tau positron emission tomography scans with (18)F-flortaucipir. Regional standardized uptake value ratios for the cerebral cortex and underlying white matter were compared between the 2 groups. The bvFTD patients showed increased (18)F-flortaucipir binding in the putamen and globus pallidus when compared to the healthy controls. In addition, bvFTD was associated with increased binding in the white matter regions underlying the frontal, anterior cingulate, and insula cortices. The bvFTD patients may exhibit predominantly subcortical (18)F-flortaucipir-binding pattern that is distinct from the patterns seen in AD patients. We hypothesize that the clinical characteristics of bvFTD patients may be attributable to the dysfunctional frontal-subcortical networks. However, concerns remain regarding unknown "off-target" binding in the white matter and the basal ganglia.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458018300599
DOI
10.1016/j.neurobiolaging.2018.02.015
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
유영훈(Ryu, Young Hoon)
이명식(Lee, Myung Sik)
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162232
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