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Interobserver variation in target volume for salvage radiotherapy in recurrent prostate cancer patients after radical prostatectomy using CT versus combined CT and MRI: a multicenter study (KROG 13-11)

 Eonju Lee  ;  Won Park  ;  Sung Hwan Ahn  ;  Jae Ho Cho  ;  Jin Hee Kim  ;  Kwan Ho Cho  ;  Young Min Choi  ;  Jae-Sung Kim  ;  Jin Ho Kim  ;  Hong-Seok Jang  ;  Young-Seok Kim  ;  Taek-Keun Nam 
 RADIATION ONCOLOGY JOURNAL, Vol.36(1) : 43420, 2018 
Journal Title
Issue Date
Interobserver variation ; Magnetic resonance image ; Prostate cancer ; Salvage radiotherapy ; Target volume
PURPOSE: To investigate interobserver variation in target volume delineations for prostate cancer salvage radiotherapy using planning computed tomography (CT) versus combined planning CT and magnetic resonance imaging (MRI). MATERIALS AND METHODS: Ten radiation oncologists independently delineated a target volume on the planning CT scans of five cases with different pathological status after radical prostatectomy. Two weeks later, this was repeated with the addition of planning MRI. The volumes obtained with CT only and combined CT and MRI were compared, and the effect of the addition of planning MRI on interobserver variability was assessed. RESULTS: There were large differences in clinical target volume (CTV) delineated by each observer, regardless of the addition of planning MRI (9.44-139.27 cm(3) in CT only and 7.77-122.83 cm(3) in CT plus MRI) and no significant differences in the mean and standard deviation of CTV. However, there were decreases in mean volume and standard deviation as a result of using the planning MRI. CONCLUSION: This study showed substantial interobserver variation in target volume delineation for salvage radiotherapy. The combination of planning MRI with CT tended to decrease the target volume and the variation.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
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