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Combined use of CEMIP and CA 19-9 enhances diagnostic accuracy for pancreatic cancer

Authors
 Hee Seung Lee  ;  Chan Young Jang  ;  Sun A Kim  ;  Soo Been Park  ;  Dawoon E Jung  ;  Bo Ok Kim  ;  Ha Yan Kim  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seungmin Bang  ;  Seung Woo Park  ;  Si Young Song 
Citation
 Scientific Reports, Vol.8(1) : 3383, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
Carbohydrate antigen (CA) 19-9 is the only diagnostic marker used in pancreatic cancer despite its limitations. Here, we aimed to identify the diagnostic role of CEMIP (also called KIAA1199) combined with CA 19-9 in patients with pancreatic cancer. A retrospective analysis of prospectively collected patient samples was performed to determine the benefit of diagnostic markers in the diagnosis of pancreatic cancer. We investigated CEMIP and CA 19-9 levels in 324 patients with pancreatic cancer and 49 normal controls using serum enzyme-linked immunosorbent assay. Median CA 19-9 and CEMIP levels were 410.5 U/ml (40.8-3342.5) and 0.67 ng/ml (0.40-1.08), respectively, in patients with pancreatic cancer. The AUROC for CA 19-9 and CEMIP were 0.847 (95% confidence interval [CI]: 0.806-0.888) and 0.760 (95% CI: 0.689-0.831), respectively. Combination of CA 19-9 with CEMIP showed markedly improved AUROC over CA 19-9 alone in pancreatic cancer diagnosis (0.94 vs. 0.89; P < 0.0001). CEMIP showed a diagnostic yield of 86.1% (68/79) in CA 19-9 negative pancreatic cancer. Combined use with CEMIP showed significantly improved diagnostic value compared with CA 19-9 alone in pancreatic cancer. Especially, CEMIP may be a complementary marker in pancreatic cancer patients with normal CA 19-9 levels.
Files in This Item:
T201801160.pdf Download
DOI
10.1038/s41598-018-21823-x
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김선아(Kim, Sun A) ORCID logo https://orcid.org/0000-0002-7174-3640
박승우(Park, Seung Woo) ORCID logo https://orcid.org/0000-0001-8230-964X
박정엽(Park, Jeong Youp) ORCID logo https://orcid.org/0000-0003-0110-8606
방승민(Bang, Seungmin) ORCID logo https://orcid.org/0000-0001-5209-8351
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
이희승(Lee, Hee Seung)
정문재(Chung, Moon Jae) ORCID logo https://orcid.org/0000-0002-5920-8549
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162223
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