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Multidimensional impulsivity as a mediator of early life stress and alcohol dependence

Authors
 Shin Tae Kim  ;  Syung Shick Hwang  ;  Hae Won Kim  ;  Eun Hee Hwang  ;  Jaeil Cho  ;  Jee In Kang  ;  Se Joo Kim 
Citation
 Scientific Reports, Vol.8(1) : 4104, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
Early life stress (ELS) leads to increased susceptibility to serious psychiatric problems such as alcohol dependence, but the mechanisms through which ELS affects alcohol dependence are unclear. We investigated the mediating role of multi-dimensional impulsivity in the associations between ELS and alcohol dependence. 330 male patients with alcohol dependence (mean age = 48.39) completed self-rating scales of ELS and several self-report measures of impulsivity as well as balloon analogue risk task (BART). After classifying different dimensions of impulsivity using factor analysis, structural equation modeling was conducted to test the mediation effects of impulsivity between ELS and alcohol dependence severity and social onset of hazardous drinking. Among the participants, 64.8%, 42.1% and 47.9% reported at least one episode of childhood maltreatment, sexual abuse and parental conflict, respectively. Response impulsivity-sensation seeking, reflection impulsivity and aggression partially mediated the association between ELS and severity of alcohol dependence (CFI = 0.902 and RMSEA = 0.079). Reflection impulsivity dimension partially mediated the association between ELS and social onset of hazardous drinking (CFI = 0.939, RMSEA = 0.091). These finding imply that stabilizing vulnerabilities such as reflection impulsivity via intervention programs that target young individuals with ELS may be helpful in delaying the onset of hazardous drinking and prevent alcohol dependence.
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DOI
10.1038/s41598-018-22474-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
강지인(Kang, Jee In) ORCID logo https://orcid.org/0000-0002-2818-7183
김세주(Kim, Se Joo) ORCID logo https://orcid.org/0000-0002-5438-8210
김혜원(Kim, Hae Won) ORCID logo https://orcid.org/0000-0002-9321-8361
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162187
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