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Multidimensional impulsivity as a mediator of early life stress and alcohol dependence

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author김혜원-
dc.date.accessioned2018-08-28T17:02:26Z-
dc.date.available2018-08-28T17:02:26Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162187-
dc.description.abstractEarly life stress (ELS) leads to increased susceptibility to serious psychiatric problems such as alcohol dependence, but the mechanisms through which ELS affects alcohol dependence are unclear. We investigated the mediating role of multi-dimensional impulsivity in the associations between ELS and alcohol dependence. 330 male patients with alcohol dependence (mean age = 48.39) completed self-rating scales of ELS and several self-report measures of impulsivity as well as balloon analogue risk task (BART). After classifying different dimensions of impulsivity using factor analysis, structural equation modeling was conducted to test the mediation effects of impulsivity between ELS and alcohol dependence severity and social onset of hazardous drinking. Among the participants, 64.8%, 42.1% and 47.9% reported at least one episode of childhood maltreatment, sexual abuse and parental conflict, respectively. Response impulsivity-sensation seeking, reflection impulsivity and aggression partially mediated the association between ELS and severity of alcohol dependence (CFI = 0.902 and RMSEA = 0.079). Reflection impulsivity dimension partially mediated the association between ELS and social onset of hazardous drinking (CFI = 0.939, RMSEA = 0.091). These finding imply that stabilizing vulnerabilities such as reflection impulsivity via intervention programs that target young individuals with ELS may be helpful in delaying the onset of hazardous drinking and prevent alcohol dependence.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMultidimensional impulsivity as a mediator of early life stress and alcohol dependence-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorShin Tae Kim-
dc.contributor.googleauthorSyung Shick Hwang-
dc.contributor.googleauthorHae Won Kim-
dc.contributor.googleauthorEun Hee Hwang-
dc.contributor.googleauthorJaeil Cho-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.1038/s41598-018-22474-8-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA04920-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid29515146-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameKim, Hae Won-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorKim, Hae Won-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage4104-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.8(1) : 4104, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers

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