Cited 13 times in
Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 안찬식 | - |
dc.contributor.author | 최진영 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2018-08-28T17:01:32Z | - |
dc.date.available | 2018-08-28T17:01:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162177 | - |
dc.description.abstract | BACKGROUND: A proportion of chronic hepatitis B (CHB) patients are diagnosed with advanced hepatocellular carcinoma (HCC) despite regular surveillance. AIMS: To determine predictors for HCC detection failure in CHB patients who underwent regular surveillance. METHODS: CHB patients with well-preserved liver function, who underwent ultrasonography and alpha-foetoprotein (AFP) analysis every 6 months, were enrolled. Cox regression analysis was used to identify predictors for detection failure, defined as HCC initially diagnosed at Barcelona Clinic Liver Cancer (BCLC) stage B or C. RESULTS: Of the 4590 CHB patients (mean age, 52.1 years; men, 61.6%), 169 patients were diagnosed with HCC (3.68%) and 35 (20.7%) HCC patients were initially diagnosed with HCC BCLC stage B or C. The cumulative incidence of HCC detection failure was 0.2% at year 1 and 1.3% at year 5. Multivariate analyses indicated that cirrhosis (hazard ratio [HR], 3.078; 95% CI, 1.389-6.821; P = 0.006), AFP levels >/=9 ng/mL (HR, 5.235; 95% CI, 2.307-11.957; P = 0.010), and diabetes mellitus (HR, 3.336; 95% CI, 1.341-8.296; P = 0.010) were independent predictors of HCC detection failure. Another model that incorporated liver stiffness (LS) values identified LS values >/=11.7 kPa (HR, 11.045; 95% CI, 2.066-59.037; P = 0.005) and AFP levels >/=9 ng/mL (HR, 4.802; 95% CI, 1.613-14.297; P = 0.005) as predictors of detection failure. CONCLUSIONS: In CHB patients undergoing regular surveillance with ultrasonography and alpha-foetoprotein (AFP) analysis every 6 months, the HCC detection failure rate was not high (0.8% per person; 0.1% per test). However, careful attention should be paid in patients with advanced liver fibrosis (clinical cirrhosis or LS value >11.7 kPa), high AFP levels, or diabetes mellitus, who are prone to surveillance failure. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Y E Chon | - |
dc.contributor.googleauthor | K S Jung | - |
dc.contributor.googleauthor | M-J Kim | - |
dc.contributor.googleauthor | J-Y Choi | - |
dc.contributor.googleauthor | C An | - |
dc.contributor.googleauthor | J Y Park | - |
dc.contributor.googleauthor | S H Ahn | - |
dc.contributor.googleauthor | B K Kim | - |
dc.contributor.googleauthor | S U Kim | - |
dc.contributor.googleauthor | H Park | - |
dc.contributor.googleauthor | S K Hwang | - |
dc.contributor.googleauthor | K S Rim | - |
dc.contributor.googleauthor | K-H Han | - |
dc.contributor.googleauthor | D Y Kim | - |
dc.identifier.doi | 10.1111/apt.14578 | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02268 | - |
dc.contributor.localId | A04200 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J00061 | - |
dc.identifier.eissn | 1365-2036 | - |
dc.identifier.pmid | 29492988 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.14578 | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | An, Chan Sik | - |
dc.contributor.alternativeName | Choi, Jin Young | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | An, Chan Sik | - |
dc.contributor.affiliatedAuthor | Choi, Jin Young | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.citation.volume | 47 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1201 | - |
dc.citation.endPage | 1212 | - |
dc.identifier.bibliographicCitation | ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol.47(8) : 1201-1212, 2018 | - |
dc.identifier.rimsid | 59764 | - |
dc.type.rims | ART | - |
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