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Management of subcentimetre arterially enhancing and hepatobiliary hypointense lesions on gadoxetic acid-enhanced MRI in patients at risk for HCC
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.contributor.author | 박채정 | - |
dc.contributor.author | 안찬식 | - |
dc.contributor.author | 최진영 | - |
dc.date.accessioned | 2018-08-28T17:00:39Z | - |
dc.date.available | 2018-08-28T17:00:39Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162162 | - |
dc.description.abstract | OBJECTIVES: To investigate the significance of subcentimetre (</=1 cm) arterially enhancing and hepatobiliary hypointense lesions (SAELs) observed on gadoxetic acid-enhanced magnetic resonance imaging (MRI) of patients at risk of hepatocellular carcinoma (HCC). METHODS: A SAEL was defined as a subcentimetre hypervascular nodule exhibiting a hepatobiliary phase defect on gadoxetic acid-enhanced MRI. We included 52 SAELs from 46 patients in a HCC surveillance population. The HCC reference standard was pathologic confirmation or a nodule >1 cm with typical imaging features of HCC at follow-up imaging. The malignancy rate and HCC-favourable imaging findings of SAELs were evaluated. RESULTS: The malignancy rate among SAELs was 57.7% (30/52). At diagnosis, all SAELs that progressed to overt HCC were treatable with curative intention. Venous or late dynamic phase washout was more frequently observed with malignant SAELs than with benign SAELs (57.7% vs. 30.6%; P = 0.01). If SAELs exhibiting washout were considered as HCC, sensitivity, specificity, and positive predictive value was 83.3%, 50%, and 69.4%, respectively. CONCLUSION: Among patients at risk of HCC, SAELs on gadoxetic acid-enhanced MRI exhibited high malignant potential. However, close observation may be an appropriate strategy for isolated SAELs. A washout appearance may be helpful for predicting malignancy. KEY POINTS: * Gadoxetic acid-enhanced MRI provides hepatobiliary phase (HBP) images. * Screening frequently detects subcentimetre arterially enhancing and hepatobiliary hypointense lesions (SAELs). * A majority of SAELs progressed to overt HCC within 2 years. * A venous-phase washout appearance correlated significantly with malignancy in SAELs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Management of subcentimetre arterially enhancing and hepatobiliary hypointense lesions on gadoxetic acid-enhanced MRI in patients at risk for HCC | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Chae Jung Park | - |
dc.contributor.googleauthor | Chansik An | - |
dc.contributor.googleauthor | Sumi Park | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.identifier.doi | 10.1007/s00330-017-5088-1 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A04942 | - |
dc.contributor.localId | A02268 | - |
dc.contributor.localId | A04200 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 29063251 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00330-017-5088-1 | - |
dc.subject.keyword | Diagnosis | - |
dc.subject.keyword | Gadoxetic acid | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Sensitivity and specificity | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Park, Chae Jung | - |
dc.contributor.alternativeName | An, Chan Sik | - |
dc.contributor.alternativeName | Choi, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Park, Chae Jung | - |
dc.contributor.affiliatedAuthor | An, Chan Sik | - |
dc.contributor.affiliatedAuthor | Choi, Jin Young | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1476 | - |
dc.citation.endPage | 1484 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.28(4) : 1476-1484, 2018 | - |
dc.identifier.rimsid | 59750 | - |
dc.type.rims | ART | - |
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