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Prevalence and serogroup changes of Neisseria meningitidis in South Korea, 2010-2016

Authors
 Hyukmin Lee  ;  Younghee Seo  ;  Kyung-Hyo Kim  ;  Kyungwon Lee  ;  Kang-Won Choe 
Citation
 Scientific Reports, Vol.8(1) : 5292, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat. The most common serogroup was serogroup B (overall, 36%, n = 9/25; IMD, 37%, n = 7/19), which was isolated in every year of the research period except for 2011. There were five serogroup W isolates recovered from patients in military service. W was no longer isolated after initiation of a vaccine programme for military trainees, but serogroup B caused meningitis in an army recruit training centre in 2015. In MLST analysis, 14 sequence types were found, and all isolates belonging to W showed the same molecular epidemiologic characteristics (W:P1.5-1, 2-2:F3-9:ST-8912). All isolates showed susceptibility to ceftriaxone, meropenem, ciprofloxacin, minocycline, and rifampin; however, the susceptibility rates to penicillin and ampicillin for isolates with W and C capsules were 22% and 30%, respectively.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162157
Files in This Item:
T201800979.pdf Download
DOI
10.1038/s41598-018-23365-8
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
이혁민(Lee, Hyuk Min) ORCID logo https://orcid.org/0000-0002-8523-4126
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