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Prevalence and serogroup changes of Neisseria meningitidis in South Korea, 2010-2016

DC FieldValueLanguage
dc.contributor.author이경원-
dc.contributor.author이혁민-
dc.date.accessioned2018-08-28T17:00:21Z-
dc.date.available2018-08-28T17:00:21Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162157-
dc.description.abstractDetermination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis. From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat. The most common serogroup was serogroup B (overall, 36%, n = 9/25; IMD, 37%, n = 7/19), which was isolated in every year of the research period except for 2011. There were five serogroup W isolates recovered from patients in military service. W was no longer isolated after initiation of a vaccine programme for military trainees, but serogroup B caused meningitis in an army recruit training centre in 2015. In MLST analysis, 14 sequence types were found, and all isolates belonging to W showed the same molecular epidemiologic characteristics (W:P1.5-1, 2-2:F3-9:ST-8912). All isolates showed susceptibility to ceftriaxone, meropenem, ciprofloxacin, minocycline, and rifampin; however, the susceptibility rates to penicillin and ampicillin for isolates with W and C capsules were 22% and 30%, respectively.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePrevalence and serogroup changes of Neisseria meningitidis in South Korea, 2010-2016-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorYounghee Seo-
dc.contributor.googleauthorKyung-Hyo Kim-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorKang-Won Choe-
dc.identifier.doi10.1038/s41598-018-23365-8-
dc.contributor.localIdA02649-
dc.contributor.localIdA03286-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid29593277-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Hyuk Min-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Hyuk Min-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage5292-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.8(1) : 5292, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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