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Osteogenic efficacy of BMP-2 mixed with hydrogel and bone substitute in peri-implant dehiscence defects in dogs: 16 weeks of healing

Authors
 Jae-Kook Cha  ;  Ui-Won Jung  ;  Daniel S Thoma  ;  Christoph H F Hammerle  ;  Ronald E Jung 
Citation
 CLINICAL ORAL IMPLANTS RESEARCH, Vol.29(3) : 300-308, 2018 
Journal Title
 CLINICAL ORAL IMPLANTS RESEARCH 
ISSN
 0905-7161 
Issue Date
2018
Keywords
bone morphogenetic protein-2 ; bone substitutes ; dental implants ; hydrogel ; polyethylene glycol
Abstract
OBJECTIVES: The objective of this study was to determine the effect of bone morphogenetic protein-2 (BMP-2) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (SBS) on new bone formation in peri-implant dehiscence defects after 16 weeks of healing. MATERIALS AND METHODS: A guided bone regeneration procedure was performed in box-type peri-implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) SBS+hydrogel, (iii) SBS+BMP-2/hydrogel and (iv) BMP-2/SBS+hydrogel. Volumetric analysis using micro-computed tomography and histomorphometric analysis was performed at 16 weeks post-operatively. RESULTS: The amount of new bone and the total augmented volume did not differ significantly between both BMP-treated groups and the SBS+hydrogel group (p > .05). Likewise, no histometric differences were observed in the values of new bone area and bone-to-implant contact ratio among the three augmentation groups (new bone area: 0.06 +/- 0.08, 0.19 +/- 0.20, 0.48 +/- 0.37 and 0.56 +/- 0.60 mm(2) [mean +/- standard deviation] in groups 1-4, respectively; bone-to-implant contact: 9.44 +/- 11.51%, 19.91 +/- 15.19%, 46.31 +/- 29.82% and 42.58 +/- 26.27% in groups 1-4, respectively). CONCLUSION: The osteogenic efficacy of BMP-2 on the regeneration of peri-implant bone defects was not detectable after 16 weeks regardless of the carrier materials.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/clr.13117
DOI
10.1111/clr.13117
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162124
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