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Interferon alpha-2a treatment for refractory Behcet uveitis in Korean patients

Authors
 Ji Hwan Lee  ;  Christopher Seungkyu Lee  ;  Sung Chul Lee 
Citation
 BMC Ophthalmology, Vol.18(1) : 52, 2018 
Journal Title
 BMC Ophthalmology 
Issue Date
2018
MeSH
Adult ; Behcet Syndrome/*drug therapy ; Female ; Humans ; Immunosuppressive Agents/adverse effects/*therapeutic use ; Interferon-alpha/adverse effects/*therapeutic use ; Male ; Middle Aged ; Recombinant Proteins/adverse effects/therapeutic use ; Recurrence ; Republic of Korea ; Retrospective Studies ; Uveitis/*drug therapy ; Visual Acuity ; Young Adult
Keywords
Behcet syndrome ; Interferon-alpha ; Therapeutics ; Uveitis
Abstract
BACKGROUND: To evaluate therapeutic outcomes of interferon alpha-2a (IFNalpha2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents. METHODS: This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. IFNalpha2a was administered at a dose of 3 million IU 3 times per week. Clinical response, relapse rate, and change of visual acuity were evaluated. RESULTS: The mean age of patients was 39.60 +/- 9.21 years, and the median treatment duration was 6 months. Four of the 5 patients (80%) presented with responses to IFNalpha2a without any uveitis attack during the treatment period. The mean number of uveitis attacks/year per patient during the treatment was 0.40 +/- 0.89. The mean log of the Minimum Angle of Resolution visual acuity improved from 1.44 +/- 0.38 at baseline to 1.02 +/- 0.58 at the final follow up. CONCLUSIONS: IFNalpha2a is an effective therapy for Behcet uveitis refractory to conventional immunosuppressants in Korean patients.
Files in This Item:
T201800746.pdf Download
DOI
10.1186/s12886-018-0719-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Ji Hwan(이지환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162106
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