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Linear Micro-patterned Drug Eluting Balloon (LMDEB) for Enhanced Endovascular Drug Delivery

Authors
 KangJu Lee  ;  Seul Gee Lee  ;  Ilkwang Jang  ;  Seung Hyun Park  ;  Dasom Yang  ;  Il Ho Seo  ;  Sung-Kyung Bong  ;  Duk Hwan An  ;  Min Kwon Lee  ;  In Kwon Jung  ;  Yong Hoon Jang  ;  Jung Sun Kim  ;  WonHyoung Ryu 
Citation
 SCIENTIFIC REPORTS, Vol.8(1) : 3666, 2018 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2018
Abstract
In-stent restenosis (ISR) often occurs after applying drug eluting stents to the blood vessels suffering from atherosclerosis or thrombosis. For treatment of ISR, drug eluting balloons (DEB) have been developed to deliver anti-proliferative drugs to the lesions with ISR. However, there are still limitations of DEB such as low drug delivery efficiency and drug loss to blood flow. Although most researches have focused on alteration of drug formulation for more efficient drug delivery, there are few studies that have attempted to understand and utilize the contact modality of DEB drug delivery. Here, we developed a linear micro-patterned DEB (LMDEB) that applied higher contact pressure to enhance drug stamping to vascular tissue. Ex vivo and in vivo studies confirmed that higher contact pressure from micro-patterns increased the amount of drug delivered to the deeper regions of vessel. Finite element method simulation also showed significant increase of contact pressure between endothelium and micro-patterns. Quantitative analysis by high performance liquid chromatography indicated that LMDEBs delivered 2.3 times higher amount of drug to vascular tissue in vivo than conventional DEBs. Finally, efficacy studies using both atherosclerotic and ISR models demonstrated superior patency of diseased vessels treated with LMDEB compared to those treated with DEB.
Files in This Item:
T201800567.pdf Download
DOI
10.1038/s41598-018-21649-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162067
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