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Long-term Clinical Outcomes of Phototherapeutic Keratectomy in Corneas With Granular Corneal Dystrophy Type 2 Exacerbated After LASIK

 Ikhyun Jun  ;  Ji Won Jung  ;  Young Joon Choi  ;  Tae-Im Kim  ;  Kyoung Yul Seo  ;  Eung Kweon Kim 
 JOURNAL OF REFRACTIVE SURGERY, Vol.34(2) : 132-139, 2018 
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Adult ; Cornea/physiopathology ; Hereditary/etiology/physiopathology/*surgery Corneal Dystrophies ; Female ; Follow-Up Studies ; Fourier Analysis ; Humans ; Laser In Situ/*adverse effects Keratomileusis ; Excimer/*therapeutic use Lasers ; Male ; Middle Aged ; Photorefractive Keratectomy/*methods ; Recurrence ; Ocular/physiology Refraction ; Retrospective Studies ; Optical Coherence Tomography ; Treatment Outcome ; Visual Acuity/physiology
PURPOSE: To investigate the long-term clinical outcomes and recurrence patterns of phototherapeutic keratectomy (PTK) in patients with granular corneal dystrophy type 2 (GCD2) exacerbated after LASIK. METHODS: Fifty-one patients (76 eyes) with GCD2 exacerbated after LASIK who underwent PTK between January 2007 and February 2017 were included. Participants underwent ophthalmic examination, including slit-lamp microscopy, corrected distance visual acuity (CDVA), slit-lamp photography, and Fourier domain optical coherence tomography at preoperative and postoperative visits. PTK was performed using VISX S4 IR (VISX, Inc., Santa Clara, CA). Visual acuity, complications, interval, and contributing factors of recurrence were evaluated. RESULTS: The follow-up period ranged from 1 to 108 months (mean: 35.22 months). The mean logMAR CDVA was 0.55 +/- 0.43 (Snellen equivalent 20/80) preoperatively and 0.09 +/- 0.43 (Snellen equivalent 20/25) at 3 months postoperatively. Forty-five (61.6%) eyes developed biomicroscopic recurrence at a mean of 18.6 months after PTK; 20 (27.4%) eyes developed significant recurrence at a mean of 31.3 months after PTK. The flap removal group demonstrated better CDVA at 3 years after surgery and lower recurrence and complication rates than the flap conservation group. Multivariate analysis revealed that flap removal remarkably reduced the risk of both any sign of and significant recurrence. CONCLUSIONS: PTK improved corneal transparency and visual acuity in patients with GCD2 exacerbated after LASIK, although GCD2 eventually recurred. PTK with flap removal was superior to PTK with flap conservation in terms of visual acuity, recurrence, and complications. [J Refract Surg. 2018;34(2):132-139.].
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae-Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Jun, Ik Hyun(전익현) ORCID logo https://orcid.org/0000-0002-2160-1679
Choi, Young Joon(최영준)
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