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Long-term Clinical Outcomes of Phototherapeutic Keratectomy in Corneas With Granular Corneal Dystrophy Type 2 Exacerbated After LASIK

Authors
 Ikhyun Jun  ;  Ji Won Jung  ;  Young Joon Choi  ;  Tae-Im Kim  ;  Kyoung Yul Seo  ;  Eung Kweon Kim 
Citation
 Journal of Refractive Surgery, Vol.34(2) : 132-139, 2018 
Journal Title
 Journal of Refractive Surgery 
ISSN
 1081-597X 
Issue Date
2018
MeSH
Adult ; Cornea/physiopathology ; Hereditary/etiology/physiopathology/*surgery Corneal Dystrophies ; Female ; Follow-Up Studies ; Fourier Analysis ; Humans ; Laser In Situ/*adverse effects Keratomileusis ; Excimer/*therapeutic use Lasers ; Male ; Middle Aged ; Photorefractive Keratectomy/*methods ; Recurrence ; Ocular/physiology Refraction ; Retrospective Studies ; Optical Coherence Tomography ; Treatment Outcome ; Visual Acuity/physiology
Abstract
PURPOSE: To investigate the long-term clinical outcomes and recurrence patterns of phototherapeutic keratectomy (PTK) in patients with granular corneal dystrophy type 2 (GCD2) exacerbated after LASIK. METHODS: Fifty-one patients (76 eyes) with GCD2 exacerbated after LASIK who underwent PTK between January 2007 and February 2017 were included. Participants underwent ophthalmic examination, including slit-lamp microscopy, corrected distance visual acuity (CDVA), slit-lamp photography, and Fourier domain optical coherence tomography at preoperative and postoperative visits. PTK was performed using VISX S4 IR (VISX, Inc., Santa Clara, CA). Visual acuity, complications, interval, and contributing factors of recurrence were evaluated. RESULTS: The follow-up period ranged from 1 to 108 months (mean: 35.22 months). The mean logMAR CDVA was 0.55 +/- 0.43 (Snellen equivalent 20/80) preoperatively and 0.09 +/- 0.43 (Snellen equivalent 20/25) at 3 months postoperatively. Forty-five (61.6%) eyes developed biomicroscopic recurrence at a mean of 18.6 months after PTK; 20 (27.4%) eyes developed significant recurrence at a mean of 31.3 months after PTK. The flap removal group demonstrated better CDVA at 3 years after surgery and lower recurrence and complication rates than the flap conservation group. Multivariate analysis revealed that flap removal remarkably reduced the risk of both any sign of and significant recurrence. CONCLUSIONS: PTK improved corneal transparency and visual acuity in patients with GCD2 exacerbated after LASIK, although GCD2 eventually recurred. PTK with flap removal was superior to PTK with flap conservation in terms of visual acuity, recurrence, and complications. [J Refract Surg. 2018;34(2):132-139.].
Full Text
https://www.healio.com/ophthalmology/journals/jrs/2018-2-34-2/%7B11b82c77-676f-4b53-b2d0-377a39d69cd0%7D/long-term-clinical-outcomes-of-phototherapeutic-keratectomy-in-corneas-with-granular-corneal-dystrophy-type-2-exacerbated-after-lasik
DOI
10.3928/1081597x-20171220-01
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
김응권(Kim, Eung Kweon) ORCID logo https://orcid.org/0000-0002-1453-8042
김태임(Kim, Tae Im) ORCID logo https://orcid.org/0000-0001-6414-3842
서경률(Seo, Kyuong Yul) ORCID logo https://orcid.org/0000-0002-9855-1980
전익현(Jun, Ik Hyun) ORCID logo https://orcid.org/0000-0002-2160-1679
최영준(Choi, Young Joon)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162066
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