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Tau Positron Emission Tomography Imaging in Degenerative Parkinsonisms

Authors
 Chul Hyoung Lyoo  ;  Hanna Cho  ;  Jae Yong Choi  ;  Young Hoon Ryu  ;  Myung Sik Lee 
Citation
 Journal of Movement Disorders, Vol.11(1) : 43112, 2018 
Journal Title
 Journal of Movement Disorders 
ISSN
 2093-4939 
Issue Date
2018
Keywords
Tau ; parkinsonism ; positron emission tomography
Abstract
In recent years, several radiotracers that selectively bind to pathological tau proteins have been developed. Evidence is emerging that binding patterns of in vivo tau positron emission tomography (PET) studies in Alzheimer's disease (AD) patients closely resemble the distribution patterns of known neurofibrillary tangle pathology, with the extent of tracer binding reflecting the clinical and pathological progression of AD. In Lewy body diseases (LBD), tau PET imaging has clearly revealed cortical tau burden with a distribution pattern distinct from AD and increased cortical binding within the LBD spectrum. In progressive supranuclear palsy, the globus pallidus and midbrain have shown increased binding most prominently. Tau PET patterns in patients with corticobasal syndrome are characterized by asymmetrical uptake in the motor cortex and underlying white matter, as well as in the basal ganglia. Even in the patients with multiple system atrophy, which is basically a synucleinopathy, (18)F-flortaucipir, a widely used tau PET tracer, also binds to the atrophic posterior putamen, possibly due to off-target binding. These distinct patterns of tau-selective radiotracer binding in the various degenerative parkinsonisms suggest its utility as a potential imaging biomarker for the differential diagnosis of parkinsonisms.
Files in This Item:
T201800538.pdf Download
DOI
10.14802/jmd.17071
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung)
유영훈(Ryu, Young Hoon)
이명식(Lee, Myung Sik)
조한나(Cho, Hanna)
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162046
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