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Distinct patterns of amyloid-dependent tau accumulation in Lewy body diseases

 Seung Ha Lee  ;  Hanna Cho  ;  Jae Yong Choi  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
 Movement Disorders, Vol.33(2) : 262-272, 2018 
Journal Title
 Movement Disorders 
Issue Date
18F-AV-1451 ; tau ; positron emission tomography ; Lewy body disease ; dementia with Lewy bodies
BACKGROUND: In addition to Lewy body pathology, amyloid-beta plaques and neurofibrillary tangles that are characteristic for Alzheimer's disease are also frequently found in Lewy body diseases. OBJECTIVES: The objective of this study was to investigate tau accumulation patterns in dementia with Lewy bodies and other Lewy body diseases using in vivo (18) F-AV-1451 PET. METHODS: The study included 12 Parkinson's disease (PD) patients with normal cognition, 22 PD patients with cognitive impairment, and 18 dementia with Lewy bodies patients. In addition, 25 Alzheimer's disease patients and 25 healthy controls were included for comparison. All participants underwent (18) F-AV-1451 and (18) F-florbetaben PET scans, and cortical binding values were compared between the controls and each disease group. RESULTS: When compared with the controls, dementia with Lewy bodies patients showed slightly increased (18) F-AV-1451 binding in the primary sensorimotor and visual cortices and the parieto-temporal cortices, which failed to survive multiple comparisons. Amyloid-positive dementia with Lewy bodies patients showed significantly increased binding in the same regions when compared with controls, and even greater binding in the primary sensorimotor and visual cortices than Alzheimer's disease. Meanwhile, binding in the lateral and medial temporal cortices was less prominent than in Alzheimer's disease. In dementia with Lewy bodies, (18) F-AV-1451 binding in the occipital cortex correlated with (18) F-florbetaben binding. Amyloid-negative patients with normal cognition, patients with cognitive impairment, and dementia with Lewy bodies patients did not show increased (18) F-AV-1451 binding. CONCLUSIONS: Dementia with Lewy bodies patients may harbor (18) F-AV-1451 binding patterns distinct from Alzheimer's disease, with greater involvement of the primary cortices and less involvement of the temporal cortex. Tau burden increases in the Lewy body disease spectrum, and amyloid may play an important role in the accumulation of neocortical tau in Lewy body diseases. (c) 2017 International Parkinson and Movement Disorder Society.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
유영훈(Ryu, Young Hoon) ORCID logo https://orcid.org/0000-0002-9000-5563
이명식(Lee, Myung Sik) ORCID logo https://orcid.org/0000-0002-8413-1854
이승하(Lee, Seung Ha)
이재훈(Lee, Jae Hoon) ORCID logo https://orcid.org/0000-0002-9898-9886
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최재용(Choi, Jae Yong)
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