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Features of optical coherence tomography predictive of choroidal neovascularisation treatment response in pathological myopia in association with fluorescein angiography

 Dong Hyun Lee  ;  Hyun Goo Kang  ;  Sung Chul Lee  ;  Min Kim 
 BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.102(2) : 238-242, 2018 
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Adult ; Aged ; Angiogenesis Inhibitors/administration & dosage ; Bevacizumab/*administration & dosage ; Choroid/*pathology ; Choroidal Neovascularization/*diagnosis/etiology ; Female ; Fluorescein Angiography/*methods ; Follow-Up Studies ; Fovea Centralis/*pathology ; Fundus Oculi ; Humans ; Intravitreal Injections ; Male ; Middle Aged ; Degenerative/complications/diagnosis/*drug therapy Myopia ; Predictive Value of Tests ; Retrospective Studies ; Optical Coherence/*methods Tomography ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity
fluorescein angiography ; myopic choroidal neovascularization ; optical coherence tomography ; pathologic myopia ; treatment response
BACKGROUND/AIMS: The aim of this study was to evaluate the usefulness of several optical coherence tomography (OCT) findings to estimate choroidal neovascularisation (CNV) activity in pathological myopia using fluorescein angiography (FA) as a reference. METHODS: This was a single-centre, retrospective study. The medical records of patients with active myopic CNV who received intravitreal bevacizumab treatment were reviewed. Parameters to monitor CNV activity were morphological features of CNV on OCT, such as CNV height, central foveal thickness, intraretinal cysts, subretinal fluid, fuzziness of the CNV border, CNV network area on FA, and haemorrhage or exudation on fundus photo. RESULTS: There were 46 patients with active CNV enrolled in this study. After intravitreal bevacizumab treatment, all the previously mentioned parameters of CNV were significantly improved. Using logistic regression analyses with backward elimination, the fuzzy border seen on OCT showed the most significant correlation with improvement of leakage on FA, when compared with other variables such as intraretinal cysts, subretinal fluid or central foveal thickness (R(2)=0.324, p=0.009). CONCLUSION: Our study showed that the fuzziness of the hyper-reflective CNV margin showed the most significant improvement and the strongest correlation with the improvement of CNV leakage on FA after intravitreal bevacizumab injections, suggesting its important role as an OCT parameter for the assessment of myopic CNV activity.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Goo(강현구) ORCID logo https://orcid.org/0000-0001-8359-9618
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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