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Retinal Layer Segmentation After Silicone oil or Gas Tamponade for Macular-on Retinal Detachment using Optical Coherence Tomography

 Lee, Sung Hoon  ;  Han, Jong Wook  ;  Byeon, Suk Ho  ;  Kim, Sung Soo  ;  Koh, Hyoung Jun  ;  Lee, Sung Chul  ;  Kim, Min 
 Retina- the Journal of Retinal and Vitreous Diseases, Vol.38(2) : 310-319, 2018 
Journal Title
 Retina- the Journal of Retinal and Vitreous Diseases 
Issue Date
Endotamponade/adverse effects* ; Endotamponade/methods ; Female ; Fluorocarbons/administration & dosage* ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnosis* ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Retinal Detachment/diagnosis ; Retinal Detachment/physiopathology ; Retinal Detachment/surgery* ; Retrospective Studies ; Silicone Oils/administration & dosage ; Silicone Oils/adverse effects* ; Tomography, Optical Coherence/methods ; Treatment Outcome ; Visual Acuity* ; Vitrectomy/adverse effects* ; Vitrectomy/methods
PURPOSE: To evaluate and compare the effect of silicone oil and gas on the thickness of all retinal layers in eyes with macula-on retinal detachment (RD). METHODS: Three hundred and sixty-seven eyes of 367 patients who received silicone oil tamponade and 310 eyes of 310 patients who received gas tamponade for the treatment of rhegmatogenous RD were initially reviewed. Automated retinal segmentation method using Spectralis optical coherence tomography was used for analysis. The primary outcome measure was the change in thickness of each retinal layer in the central 1 mm zone (silicone oil vs. gas tamponade). The secondary outcome measure was best-corrected visual acuity at postoperative 6 months and 9 months after primary RD surgery. RESULTS: Eyes in the silicone oil group (n = 33) had a statistically significant decrease in total retinal thickness of 23.61 + 17.01 μm and in the thickness of all retinal layers, except for photoreceptor layer at 6 months after primary RD surgery (P < 0.001). In the gas group (n = 31), the postoperative change in total retinal thickness was only 0.14 ± 7.26 μm (P = 0.93), with no significant decrease in any of the individual retinal layers. Postoperatively, the best-corrected visual acuity in the silicone oil groups was significantly worse than that in the gas group at 6 months and 9 months after RD surgery (P = 0.003 and P = 0.004, respectively). The postoperative decrease of the ganglion cell layer, outer plexiform layer, and outer nuclear layer thicknesses showed significant correlation with best-corrected visual acuity in the silicone oil group (all P < 0.05). CONCLUSION: Silicone oil tamponade had a significant impact on the reduction of retinal thickness and that the reduction of ganglion cell layer, outer plexiform layer, and outer nuclear layer thicknesses showed the strongest correlation with worse visual acuity outcome.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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