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Altered resting-state functional connectivity in patients with obsessive-compulsive disorder: A magnetoencephalography study

Authors
 Min Jung Koh  ;  Jaeho Seol  ;  Jee In Kang  ;  Bong Soo Kim  ;  Kee Namkoong  ;  Jin Woo Chang  ;  Se Joo Kim 
Citation
 International Journal of Psychophysiology, Vol.123 : 80-87, 2018 
Journal Title
 International Journal of Psychophysiology 
ISSN
 0167-8760 
Issue Date
2018
Keywords
Functional hub ; Magnetoencephalography ; Obsessive-compulsive disorder (OCD) ; Phase-locking value ; Resting-state functional connectivity ; Synchronization
Abstract
Aberrant cortical-striatal-thalamic-cortical circuits have been implicated in the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological basis of OCD remains unclear. We compared patterns of functional connectivity in patients with OCD and in healthy controls using resting-state magnetoencephalography (MEG). Participants comprised 24 patients with OCD (21 men, 3 women) and 22 age- and sex-matched healthy controls (19 men, 3 women). Resting-state measurements were obtained over a 6-min period using a 152-channel whole-head MEG system. We examined group differences in oscillatory activity and distribution of functional cortical hubs based on the nodal centrality of phase-locking value (PLV) maps. Differences in resting-state functional connectivity were examined through PLV analysis in selected regions of interest based on these two findings. Patients with OCD demonstrated significantly lower delta band activity in the cortical regions of the limbic lobe, insula, orbitofrontal, and temporal regions, and theta band activity in the parietal lobe regions than healthy controls. Patients with OCD exhibited fewer functional hubs in the insula and orbitofrontal cortex and additional hubs in the cingulate and temporo-parietal regions. The OCD group exhibited significantly lower phase synchronization among the insula, orbitofrontal cortex, and cortical regions of the limbic lobe in all band frequencies, except in the delta band. Altered functional networks in the resting state may be associated with the pathophysiology of OCD. These MEG findings indicate that OCD is associated with decreased functional connectivity in terms of phase synchrony, particularly in the insula, orbitofrontal cortex, and cortical regions of the limbic lobe.
Full Text
https://www.sciencedirect.com/science/article/pii/S0167876017303525
DOI
10.1016/j.ijpsycho.2017.10.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161925
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