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Activated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma

DC Field Value Language
dc.contributor.author김경원-
dc.contributor.author설인숙-
dc.contributor.author손명현-
dc.contributor.author심두희-
dc.contributor.author이재면-
dc.contributor.author홍정연-
dc.contributor.author김미나-
dc.date.accessioned2018-08-28T16:46:08Z-
dc.date.available2018-08-28T16:46:08Z-
dc.date.issued2018-
dc.identifier.issn1073-449X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161916-
dc.description.abstractRATIONALE: The activated leukocyte cell adhesion molecule (ALCAM) is a cluster of differentiation 6 ligand that is important for stabilizing the immunological synapse and inducing T-cell activation and proliferation. OBJECTIVES: In this study, we investigated the role of ALCAM in the development of inflammation in allergic asthma. METHODS: An ovalbumin (OVA)-induced allergic asthma model was established in wild-type (WT) and ALCAM-deficient (ALCAM(-/-)) mice. T-cell proliferation was evaluated in cocultures with dendritic cells (DCs). Bone marrow-derived dendritic cells (BMDCs) from WT and ALCAM(-/-) mice were cultured and adoptively transferred to OT-II mice for either OVA sensitization or challenge. An anti-ALCAM antibody was administered to assess its therapeutic potential. ALCAM concentrations in the sputum and serum of children with asthma were quantified by ELISA. MEASUREMENTS AND MAIN RESULTS: Inflammatory responses were lower in ALCAM(-/-) mice than in WT mice, and T cells cocultured with DCs from ALCAM(-/-) mice showed reduced proliferation relative to those cocultured with DCs from WT mice. A decreased inflammatory response was observed upon adoptive transfer of BMDCs from ALCAM(-/-) mice as compared with that observed after transfer of BMDCs from WT mice. In addition, anti-ALCAM antibody-treated mice showed a reduced inflammatory response, and sputum and serum ALCAM concentrations were higher in children with asthma than in control subjects. CONCLUSIONS: ALCAM contributes to OVA-induced allergic asthma by stimulating T-cell activation and proliferation, suggesting it as a potential therapeutic target for allergic asthma.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Thoracic Society-
dc.relation.isPartOfAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleActivated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorMi Na Kim-
dc.contributor.googleauthorJung Yeon Hong-
dc.contributor.googleauthorDoo Hee Shim-
dc.contributor.googleauthorIn Suk Sol-
dc.contributor.googleauthorYun Seon Kim-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorJae Myun Lee-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.identifier.doi10.1164/rccm.201703-0532OC-
dc.contributor.localIdA00303-
dc.contributor.localIdA01941-
dc.contributor.localIdA01967-
dc.contributor.localIdA02191-
dc.contributor.localIdA03071-
dc.contributor.localIdA04431-
dc.relation.journalcodeJ00112-
dc.identifier.eissn1535-4970-
dc.identifier.pmid29394080-
dc.identifier.urlhttps://www.atsjournals.org/doi/10.1164/rccm.201703-0532OC-
dc.subject.keywordT-cell proliferation-
dc.subject.keywordactivated leukocyte cell adhesion molecule-
dc.subject.keywordasthma-
dc.subject.keyworddendritic cell-
dc.subject.keywordimmune synapse-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameSol, In Suk-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameShim, Doo Hee-
dc.contributor.alternativeNameLee, Jae Myun-
dc.contributor.alternativeNameHong, Jung Yeon-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorSol, In Suk-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorShim, Doo Hee-
dc.contributor.affiliatedAuthorLee, Jae Myun-
dc.contributor.affiliatedAuthorHong, Jung Yeon-
dc.citation.volume197-
dc.citation.number8-
dc.citation.startPage994-
dc.citation.endPage1008-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol.197(8) : 994-1008, 2018-
dc.identifier.rimsid59507-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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