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Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta

 Sunhee Jung  ;  Suk-Won Song  ;  Sak Lee  ;  Se Hoon Kim  ;  Soo-Jin Ann  ;  Eun Jeong Cheon  ;  Gijong Yi  ;  Eui-Young Choi  ;  Seung Hyun Lee  ;  Hyun-Chel Joo  ;  Do Hyun Ryu  ;  Sang-Hak Lee  ;  Geum-Sook Hwang 
 Atherosclerosis, Vol.269 : 21-28, 2018 
Journal Title
Issue Date
Atherosclerosis ; Lipidomics ; Metabolomics ; Quinic acid
BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory disease characterized by thickening of the arterial wall. However, a limited number of studies have been conducted on metabolic profiling of human aortic tissue. METHODS: We applied liquid chromatography/mass spectrometry to perform global and targeted profiling of plaque-containing aortic tissue. The aorta samples included plaque-containing (n = 18) and control plaque-free (n = 24) aortic tissue from patients undergoing aortic surgery. RESULTS: The metabolic patterns of atherosclerotic and control vessels were significantly different. Metabolites in the purine and glutathione pathways showed dysregulation of oxidative stress in plaques, and levels of glucosylceramide, tryptophan, and kynurenine, which are related to inflammation, were also altered. Interestingly, an increased level of quinic acid was observed in plaques (p < 0.000), and we demonstrated an inhibitory effect of quinic acid on inflammatory activation and oxidative stress in macrophages. CONCLUSIONS: Our study provides insight into the disease mechanism and potential markers of atherosclerosis through comprehensive metabolic profiling of human aortic tissue samples containing plaque.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
송석원(Song, Suk Won) ORCID logo https://orcid.org/0000-0002-9850-9707
이기종(Yi, Gi Jong)
이삭(Lee, Sak) ORCID logo https://orcid.org/0000-0001-6130-2342
이상학(Lee, Sang Hak) ORCID logo https://orcid.org/0000-0002-4535-3745
이승현(Lee, Seung Hyun) ORCID logo https://orcid.org/0000-0002-0311-6565
주현철(Joo, Hyun Chel) ORCID logo https://orcid.org/0000-0002-6842-2942
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
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