Cited 21 times in
Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 송석원 | - |
dc.contributor.author | 이기종 | - |
dc.contributor.author | 이삭 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 주현철 | - |
dc.contributor.author | 최의영 | - |
dc.date.accessioned | 2018-08-28T16:40:17Z | - |
dc.date.available | 2018-08-28T16:40:17Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161823 | - |
dc.description.abstract | BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory disease characterized by thickening of the arterial wall. However, a limited number of studies have been conducted on metabolic profiling of human aortic tissue. METHODS: We applied liquid chromatography/mass spectrometry to perform global and targeted profiling of plaque-containing aortic tissue. The aorta samples included plaque-containing (n = 18) and control plaque-free (n = 24) aortic tissue from patients undergoing aortic surgery. RESULTS: The metabolic patterns of atherosclerotic and control vessels were significantly different. Metabolites in the purine and glutathione pathways showed dysregulation of oxidative stress in plaques, and levels of glucosylceramide, tryptophan, and kynurenine, which are related to inflammation, were also altered. Interestingly, an increased level of quinic acid was observed in plaques (p < 0.000), and we demonstrated an inhibitory effect of quinic acid on inflammatory activation and oxidative stress in macrophages. CONCLUSIONS: Our study provides insight into the disease mechanism and potential markers of atherosclerosis through comprehensive metabolic profiling of human aortic tissue samples containing plaque. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Sunhee Jung | - |
dc.contributor.googleauthor | Suk-Won Song | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Soo-Jin Ann | - |
dc.contributor.googleauthor | Eun Jeong Cheon | - |
dc.contributor.googleauthor | Gijong Yi | - |
dc.contributor.googleauthor | Eui-Young Choi | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Hyun-Chel Joo | - |
dc.contributor.googleauthor | Do Hyun Ryu | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Geum-Sook Hwang | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2017.11.034 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A02028 | - |
dc.contributor.localId | A02697 | - |
dc.contributor.localId | A02807 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A03960 | - |
dc.contributor.localId | A04165 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 29253644 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021915017314193 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Lipidomics | - |
dc.subject.keyword | Metabolomics | - |
dc.subject.keyword | Quinic acid | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Song, Suk Won | - |
dc.contributor.alternativeName | Yi, Gi Jong | - |
dc.contributor.alternativeName | Lee, Sak | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.alternativeName | Joo, Hyun Chel | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Song, Suk Won | - |
dc.contributor.affiliatedAuthor | Yi, Gi Jong | - |
dc.contributor.affiliatedAuthor | Lee, Sak | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Joo, Hyun Chel | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.citation.volume | 269 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 28 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.269 : 21-28, 2018 | - |
dc.identifier.rimsid | 59415 | - |
dc.type.rims | ART | - |
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